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1. (WO2007005583) COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005583 International Application No.: PCT/US2006/025536
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07F 9/09 (2006.01) ,C07F 9/24 (2006.01) ,C07F 9/141 (2006.01) ,C07D 263/14 (2006.01) ,C07C 271/16 (2006.01) ,C07C 217/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
22
Amides of acids of phosphorus
24
Esteramides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
141
Esters of phosphorous acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
10
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
14
with radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
16
to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02
having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
28
having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
Applicants:
EISAI CO., LTD. [JP/JP]; 6-10 Koishi Kawa, 4-Chome Bunky-ky, Tokyo, 112-8088, JP (AllExceptUS)
FANG, Francis, G. [US/US]; US (UsOnly)
FOY, James, E. [US/US]; US (UsOnly)
HAWKINS, Lynn [US/US]; US (UsOnly)
LEMELIN, Charles [CA/US]; US (UsOnly)
LESCARBEAU, Andre [CA/US]; US (UsOnly)
NIU, Xiang [CN/US]; US (UsOnly)
WU, Kuo-ming [US/US]; US (UsOnly)
Inventors:
FANG, Francis, G.; US
FOY, James, E.; US
HAWKINS, Lynn; US
LEMELIN, Charles; US
LESCARBEAU, Andre; US
NIU, Xiang; US
WU, Kuo-ming; US
Agent:
LINDEMAN, Jeffrey, A. ; NIXON PEABODY LLP 401 9th Street, N.W., Suite 900 Washington, DC 20004, US
Priority Data:
60/695,32430.06.2005US
Title (EN) COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
(FR) COMPOSES POUR LA PREPARATION D'UN ADJUVANT IMMUNOLOGIQUE
Abstract:
(EN) The present invention provides methods for preparing TLR-4 receptor agonist E6020 formula(I): and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
(FR) La présente invention concerne des méthodes de préparation d'un agoniste des récepteurs TLR-4, l'E6020 de formule (I), ainsi que des stéréoisomères de celui-ci, lesdits composés étant utiles en tant qu'adjuvants immunologiques lorsqu'ils sont co-administrés avec des antigènes tels que des vaccins contre des maladies bactériennes et virales. L'invention concerne également des intermédiaires de synthèse.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020080031350IL187819EP1910387EP2292628JP2009502742IL213173
IL213174JP2012162562CN101213199CN103012304CA2611721JP2015051978
CN103012169AU2006265986EP3138844IN104/DELNP/2008