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1. (WO2007005559) TAT-005 AND METHODS OF ASSESSING AND TREATING CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005559 International Application No.: PCT/US2006/025483
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
C12Q 1/00 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/53 (2006.01) ,C07K 14/00 (2006.01) ,C07H 21/04 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/395 (2006.01) ,A61K 49/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
Applicants:
CAPRION PHARMACEUTICALS, INC. [CA/CA]; 7150 Alexander-Fleming Montreal, Quebec, H4S 2C8, CA (AllExceptUS)
FILGUEIRA, Marcelo [CA/CA]; CA (UsOnly)
CHELSKY, Daniel [US/CA]; CA (UsOnly)
LANOIX, Joel [CA/CA]; CA (UsOnly)
ENG, Kevin [CA/CA]; CA (UsOnly)
THIBAULT, Pierre [CA/CA]; CA (UsOnly)
FAUBERT, Denis [CA/CA]; CA (UsOnly)
JAITLY, Navdeep [CA/US]; US (UsOnly)
BRUNET, Sylvain [CA/CA]; CA (UsOnly)
AGUILERA, Frank, R.M. [CU/CA]; CA (UsOnly)
TSANG, John, S.C. [CA/US]; US (UsOnly)
HU, Michael [CA/US]; US (UsOnly)
OSTERMANN, Joachim, B. [DE/CA]; CA (UsOnly)
BOULOS, Marguerite [CA/CA]; CA (UsOnly)
KEARNEY, Paul, E. [CA/CA]; CA (UsOnly)
BUTLER, Heather [GB/CA]; CA (UsOnly)
SWAMY, Sajani [CA/GB]; GB (UsOnly)
HAMAIDI, Lyes [CA/CA]; CA (UsOnly)
Inventors:
FILGUEIRA, Marcelo; CA
CHELSKY, Daniel; CA
LANOIX, Joel; CA
ENG, Kevin; CA
THIBAULT, Pierre; CA
FAUBERT, Denis; CA
JAITLY, Navdeep; US
BRUNET, Sylvain; CA
AGUILERA, Frank, R.M.; CA
TSANG, John, S.C.; US
HU, Michael; US
OSTERMANN, Joachim, B.; CA
BOULOS, Marguerite; CA
KEARNEY, Paul, E.; CA
BUTLER, Heather; CA
SWAMY, Sajani; GB
HAMAIDI, Lyes; CA
Agent:
DECAMP, James, D.; CLARK & ELBING LLP 101 Federal Street Boston, MA 02110, US
Priority Data:
60/695,56730.06.2005US
Title (EN) TAT-005 AND METHODS OF ASSESSING AND TREATING CANCER
(FR) TAT-005 ET PROCEDES D'EVALUATION ET DE TRAITEMENT DU CANCER
Abstract:
(EN) Surprisingly, the present inventors have discovered that expression of TAT-005 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-005 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer com\ pounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-005 expression or activity, comprising: contacting a candidate compound with a TAT-005 and detecting the presence or absence of binding between said compound and said TAT-005, or detecting a change in TAT-005 expression or activity. Methods are also included for the identification of compounds that modulate TAT-005 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-005 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.
(FR) De manière surprenante, les inventeurs de cette invention ont découvert que l'expression de la protéine TAT-005 chez les patients humains est liée au cancer et que la protéine surexprimée est présente dans des fractions de membrane plasmique. Il a ainsi été découvert que la protéine TAT-005 est liée à une croissance et à un développement anormaux et peut être utilisée comme cible pour identifier des composés anticancéreux, notamment des anticorps utilisables en immunothérapie. En conséquence, l'invention concerne des procédés servant à identifier des composés qui inhibent l'expression ou l'activité de TAT-005, ces procédés comprenant les étapes suivantes : mise en contact d'un composé candidat avec une protéine TAT-005 et détection de la présence ou de l'absence de liaison entre ce composé et cette protéine TAT-005 ou détection d'une modification dans l'expression ou l'activité de TAT-005. L'invention concerne également des procédés servant à identifier des composés qui modulent l'expression ou l'activité de TAT-005, ces procédés consistant à administrer un composé à une cellule ou à une population cellulaire et à détecter une modification dans l'expression ou l'activité de TAT-005. Les procédés selon l'invention sont utiles pour identifier des composés anticancéreux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20100183630