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1. (WO2007005503) HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005503 International Application No.: PCT/US2006/025328
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
IPC:
C07D 207/09 (2006.01) ,C07D 403/12 (2006.01) ,C07D 401/12 (2006.01) ,A61K 31/4025 (2006.01) ,A61P 3/04 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
09
Radicals substituted by nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285, US (AllExceptUS)
BEAVERS, Lisa, Selsam [US/US]; US (UsOnly)
FINLEY, Don, Richard [US/US]; US (UsOnly)
GADSKI, Robert, Alan [US/US]; US (UsOnly)
HIPSKIND, Philip, Arthur [US/US]; US (UsOnly)
HORNBACK, William, Joseph [US/US]; US (UsOnly)
JESUDASON, Cynthia, Darshini [US/US]; US (UsOnly)
PICKARD, Richard, Todd [US/US]; US (UsOnly)
TAKAKUWA, Takako [JP/US]; US (UsOnly)
VAUGHT, Grant, Mathews [US/US]; US (UsOnly)
Inventors:
BEAVERS, Lisa, Selsam; US
FINLEY, Don, Richard; US
GADSKI, Robert, Alan; US
HIPSKIND, Philip, Arthur; US
HORNBACK, William, Joseph; US
JESUDASON, Cynthia, Darshini; US
PICKARD, Richard, Todd; US
TAKAKUWA, Takako; US
VAUGHT, Grant, Mathews; US
Agent:
WOOD, Dan, L. ; ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288, US
Priority Data:
60/696,25701.07.2005US
Title (EN) HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES
(FR) AGENTS RECEPTEURS DE L'HISTAMINE H3, PREPARATION ET UTILISATIONS THERAPEUTIQUES
Abstract:
(EN) The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)
(FR) L'invention se rapporte à de nouveaux composés de la formule 1 ou à des sels pharmaceutiquement acceptables de ces derniers qui possèdent une activité antagoniste ou agoniste inverse du récepteur à l'histamine H3, et à des procédés de préparation desdits composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant des composés de la formule 1, et des procédés d'utilisation de ces derniers pour traiter l'obésité, les déficiences cognitives, la narcolepsie et d'autres affections liées au récepteur de l'histamine H3.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2007/016216EP1904442EP2322506BRPI0613495-5JP2009500335ES2370518
US20100160319CN101263112CA2613192AU2006265997IN4926/KOLNP/2007