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1. (WO2007005462) CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005462 International Application No.: PCT/US2006/025160
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
IPC:
C07D 215/54 (2006.01) ,A61K 31/4709 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
54
attached in position 3
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
Applicants:
WYETH [US/US]; Five Giralda Farms Madison, NJ 07940, US (AllExceptUS)
TESCONI, Marc, Sadler [US/US]; US (UsOnly)
FEIGELSON, Gregg [US/US]; US (UsOnly)
STRONG, Henry [US/US]; US (UsOnly)
WEN, Hong [CN/US]; US (UsOnly)
Inventors:
TESCONI, Marc, Sadler; US
FEIGELSON, Gregg; US
STRONG, Henry; US
WEN, Hong; US
Agent:
MANDRA, Raymond, R. ; Fitzpatrick, Cella, Harper & Scinto 30 Rockefeller Plaza New York, NY 10112-3801, US
Priority Data:
60/696,38101.07.2005US
Title (EN) CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME
(FR) FORMES CRISTALLINES DE 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE, ET LEURS PROCEDES DE PREPARATION
Abstract:
(EN) This invention is directed to a crystalline 4-[(2,4-dichloro-5- methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-l-piperazinyl)propoxy]-3- quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 20 angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109ºC to about 115ºC.
(FR) La présente invention se rapporte à un monohydrate de 4-[(2,4-dichloro-5- méthoxyphényl)amino]-6-méthoxy-7-[3-(4-méthyl-l-pipérazinyl)propoxy]-3- quinolinecarbonitrile cristallin, qui présente un diagramme de diffraction selon lequel les angles 2? (°) de crêtes importantes sont d'environ : 9,19, 11,48, 14,32, 19,16, 19,45, 20,46, 21,29, 22,33, 23,96, 24,95, 25,29, 25,84, 26,55, 27,61, et 29,51, et présente également une température de transition comprise environ entre 109 ºC et 115 ºC.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080051NZ564699MXMX/a/2008/000384KR1020080028386IL188483AR054505
VN17470PE2007-0190EP1902029CR47/9596JP2009500332CN101248047
CA2613053ES2449197AU2006266045DK1902029BRPI0613574ID048.0634
MYPI 20063130TH85514IN4959/KOLNP/2007