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Machine translation
1. (WO2007005453) COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005453    International Application No.:    PCT/US2006/025138
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
IPC:
A61K 31/00 (2006.01), A61K 31/05 (2006.01), A61K 31/12 (2006.01), A61P 3/10 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street, Cambridge, MA 02138 (US) (For All Designated States Except US).
THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street, Boston, MA 02114 (US) (For All Designated States Except US).
SINCLAIR, David, A. [AU/US]; (US) (For US Only).
ALEXANDER-BRIDGE, Maria [US/US]; (US) (For US Only)
Inventors: SINCLAIR, David, A.; (US).
ALEXANDER-BRIDGE, Maria; (US)
Agent: CLAUSS, Isabelle, M.; FOLEY HOAG, LLP, 155 Seaport Boulevard, Boston, MA 02210 (US)
Priority Data:
11/174,000 01.07.2005 US
Title (EN) COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
(FR) COMPOSITIONS DESTINEES AU TRAITEMENT OU A LA PREVENTION DE L'OBESITE ET DE TROUBLES LIES A LA RESISTANCE A L'INSULINE
Abstract: front page image
(EN)Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
(FR)L'invention concerne des procédés et des compositions permettant de moduler l'activité ou le taux d'une sirtuine, traitant ou prévenant ainsi l'obésité ou un trouble lié à la résistance à l'insuline, tel que les diabètes, chez un sujet. Dans procédés exemplaires consistent à mettre en contact une cellule avec un composé activant la sirtuine ou un composé inhibiteur afin d'accroître ou de diminuer ainsi l'accumulation de gras respectivement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)