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1. (WO2007005443) THERAPEUTIC METHODS EMPLOYING PAI-1 INHIBITORS AND TRANSGENIC NON-HUMAN ANIMAL FOR SCREENING CANDIDATE PAI-1 INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005443 International Application No.: PCT/US2006/025116
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
IPC:
A61K 31/47 (2006.01) ,A61K 31/41 (2006.01) ,A61K 31/35 (2006.01) ,A01N 43/42 (2006.01) ,A01N 43/64 (2006.01) ,G01N 33/00 (2006.01) ,A01K 67/00 (2006.01) ,A01N 43/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34
having rings with one nitrogen atom as the only ring hetero atom
40
six-membered rings
42
condensed with carbocyclic rings
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64
having rings with three nitrogen atoms as the only ring hetero atoms
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02
having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04
with one hetero atom
14
six-membered rings
16
with oxygen as the ring hetero atom
Applicants:
VANDERBILT UNIVERSITY [US/US]; 1207 17th Avenue South, Suite 105 Nashville, TN 37212, US (AllExceptUS)
VAUGHAN, Douglas, E. [US/US]; US (UsOnly)
EREN, Mesut [TR/US]; US (UsOnly)
Inventors:
VAUGHAN, Douglas, E.; US
EREN, Mesut; US
Agent:
TAYLOR, Arles, A., Jr.; JENKINS WILSON TAYLOR & HUNT, P.A. SUITE 1200, UNIVERSITY TOWER 3100 Tower Boulevard Durham, NC 27707, US
Priority Data:
11/171,08329.06.2005US
Title (EN) THERAPEUTIC METHODS EMPLOYING PAI-1 INHIBITORS AND TRANSGENIC NON-HUMAN ANIMAL FOR SCREENING CANDIDATE PAI-1 INHIBITORS
(FR) METHODES THERAPEUTIQUES FAISANT INTERVENIR DES INHIBITEURS DU PAI-1 ET DES ANIMAUX NON HUMAINS TRANSGENIQUES POUR LE CRIBLAGE D'INHIBITEURS DU PAI-1 CANDIDATS
Abstract:
(EN) A method of treating a warm-blooded vertebrate animal having a medical condition in need of treatment with a composition that exhibits PAI-I inhibition activity is disclosed. A transgenic non-human animal having incorporated into its genome a PAI-I gene encoding a biologically active PAI-I polypeptide is also disclosed, as is a PAI-I transgene construct encoding a biologically active PAI 1 polypeptide (Figure 1) useful for preparing the transgenic non-human animal. A method of testing a candidate composition for PAI-I inhibition activity using the same transgenic non-human animal is also disclosed.
(FR) L'invention concerne une méthode thérapeutique pour un animal vertébré à sang chaud atteint d'un état pathologique nécessitant un traitement à l'aide d'une composition qui présente une activité inhibitrice du PAI-1. La méthode de l'invention comprend les étapes qui consistent : à administrer une dose thérapeutique efficace de la composition à un animal vertébré à sang chaud atteint d'un état pathologique sélectionné dans le groupe comprenant alopécie, perte de poids non désirée, maladie d'Alzheimer, amyloïdose systémique, myélofibrose, calvitie hippocratique, glomérulosclérose, maladie veino-occlusive (VOD), fibrose pulmonaire, obésité, stéatohépatite non alcoolique (NASH), ostéoporose, ostéopénie, syndrome des ovaires polykystiques (SOPK), et combinaisons de ceux-ci; et à observer une amélioration dans l'état pathologique chez l'animal vertébré à sang chaud atteint dudit état pathologique. L'invention concerne également une méthode d'essai d'une composition candidate pour l'activité inhibitrice du PAI-1. Cette méthode comprend les étapes qui consistent : à obtenir un animal vertébré à sang chaud non humain transgénique qui comprend dans son génome un gène PAI-1 codant pour un polypeptide PAI-1 actif sur le plan biologique, le gène PAI-1 étant présent dans le génome en quantité efficace pour conférer une surexpression chez l'animal non humain transgénique du polypeptide PAI-1; à administrer la composition à l'animal non humain transgénique; et à observer l'animal non humain transgénique en vue de déterminer chez ce dernier un changement indiquant une inhibition de l'activité du PAI-1. L'invention concerne en outre un animal non humain transgénique à utiliser dans ledit procédé, ainsi qu'une construction transgénique de PAI-1 codant pour un polypeptide PAI-1 actif sur le plan biologique servant à préparer ledit animal non humain transgénique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)