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1. (WO2007005248) IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4&bgr;, 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005248    International Application No.:    PCT/US2006/023698
Publication Date: 11.01.2007 International Filing Date: 19.06.2006
IPC:
C07D 311/26 (2006.01)
Applicants: MARS, INCORPORATED [US/US]; 6885 Elm Street, McLean, VA 22101-3383 (US) (For All Designated States Except US).
ROMANCZYK, Leo, Jr., [US/US]; (US) (For US Only).
SHARMA, Pradeep, K. [US/US]; (US) (For US Only).
KOLCHINSKI, Alexander, G. [US/US]; (US) (For US Only).
SHEA, Helene, A. [US/US]; (US) (For US Only).
GOU, Yanni [US/US]; (US) (For US Only)
Inventors: ROMANCZYK, Leo, Jr.,; (US).
SHARMA, Pradeep, K.; (US).
KOLCHINSKI, Alexander, G.; (US).
SHEA, Helene, A.; (US).
GOU, Yanni; (US)
Agent: KELLEY, Margaret, B.; Gibbons, Del Deo, Dolan, Griffinger & Vecchione, One Riverfront Plaza, Newark, NJ 07102-9506 (US)
Priority Data:
11/169,860 29.06.2005 US
Title (EN) IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4&bgr;, 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES
(FR) PROCEDES AMELIORES DE PREPARATION DE MONOMERES DE CATECHINE ET D'(-)-EPICATECHINE PROTEGES, PERMETTANT DE COUPLER LES MONOMERES PROTEGES AVEC UN MONOMERE D'EPICATECHINE PROTEGE ACTIVE, ET DE PREPARATION DE DIMERES D'EPICATECHINE-(4?, 8)-EPICATECHINE OU -CATECHINE ET DE LEURS DIGALLATES
Abstract: front page image
(EN)Improved processes for the preparation of tetra-O-benzyl protected -(+)-catechin, for the coupling of the tetra-O-benzyl protected -(+)-catechin or -(-)-epicatechin with a C-4 activated, tetra-O-benzyl protected -(-)-epicatechin, for the galloylation of the (-)-epicatechin-(4&bgr;,8)-(+)-catechin or -(-)-epicatechin dimer to the dimer digallates, and for the deprotection (i.e., debenzylation) of the protected -(-)-epicatechin dimers and protected -(-)-epicatechin dimer digallates are disclosed.
(FR)L'invention concerne des procédés améliorés de préparation de -(+)-catéchine à protection tétra-O-benzyle permettant de coupler la -(+)-catéchine ou -(-)-épicatéchine à protection tétra-O-benzyle avec une -(-)-épicatéchine à protection tétra-O-benzyle activée C-4, pour la galloylation de l'(-)-épicatéchine-(4ß,8)-(+)-catéchine ou dimère d'-(-)-épicatéchine aux digallates de dimère, et pour la déprotection (c'est-à-dire la débenzylation) des dimères d'-(-)-épicatéchine protégés et des digallates de dimère d'-(-)-épicatéchine protégés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)