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1. (WO2007005056) PLATINUM COMPLEXES WITH MONONITRILE-CONTAINING LIGANDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005056 International Application No.: PCT/US2006/002887
Publication Date: 11.01.2007 International Filing Date: 26.01.2006
IPC:
C07F 15/00 (2006.01) ,A61K 31/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15
Compounds containing elements of the 8th Group of the Periodic System
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
Applicants:
BIONUMERIK PHARMACEUTICALS, INC. [US/US]; 8122 Datapoint Drive Suite 1250 San Antonio, Texas 78229, US (AllExceptUS)
XIAO, Zejun [CN/US]; US (UsOnly)
HAUSHEER, Frederick, H. [US/US]; US (UsOnly)
PETLURU, Pavankumar [IN/US]; US (UsOnly)
Inventors:
XIAO, Zejun; US
HAUSHEER, Frederick, H.; US
PETLURU, Pavankumar; US
Agent:
WHITAKER, Scott, A.; Bionumerik Pharmaceuticals, Inc. 8122 Datapoint Dr., Suite 1250 San Antonio, Texas 78229, US
Priority Data:
60/695,63830.06.2005US
Title (EN) PLATINUM COMPLEXES WITH MONONITRILE-CONTAINING LIGANDS
(FR) COMPLEXES DE PLATINE POURVUS DE LIGANDS CONTENANT DES MONONITRILES
Abstract:
(EN) Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L1 and L2 )which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.
(FR) Cette invention concerne des nouveaux complexes à base de platine présentant un substituant (mononitrile) lié par covalence au platine, un ou plusieurs ligands donneurs d'azote capables de former des liaisons hydrogène avec les bases dans l'ADN et ARN et des groupes partants (c'est-à-dire L1 et L2 ) qui peuvent être hydrolysés in vivo à des espèces actives qui peuvent, ensuite, former des produits d'addition coordonnés avec l'ADN ou l'ARN sur les bases Guanine ou Adénine. En outre, cette invention concerne des schémas de réactions permettant la synthèse de ces complexes de platine, ainsi que des méthodes permettant de traiter divers types de cancer par administration d'une dose pharmaceutiquement efficace de ces complexes de platine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2007/015854EP1896492JP2008544985CN101213200CA2612721AU2006266444
IN9966/DELNP/2007