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1. (WO2007005027) IDENTIFICATION OF NON-SMALL CELL LUNG CARCINOMA (NSCLC) TUMORS EXPRESSING PDGFR-ALPHA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005027 International Application No.: PCT/US2005/023858
Publication Date: 11.01.2007 International Filing Date: 05.07.2005
IPC:
G01N 33/53 (2006.01) ,G01N 33/566 (2006.01) ,A61K 38/00 (2006.01) ,A61K 35/00 (2006.01) ,A01N 37/18 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
566
using specific carrier or receptor proteins as ligand binding reagent
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
18
containing the group -CO-N, e.g. carboxylic acid amides or imides; Thio-analogues thereof
Applicants:
CELL SIGNALING TECHNOLOGY, INC. [US/US]; 166B Cummings Center Beverly, MA 01915, US (AllExceptUS)
RIKOVA, Klarisa [UZ/US]; US (UsOnly)
POLAKIEWICZ, Roberto [US/US]; US (UsOnly)
GUO, Ailan [CN/US]; US (UsOnly)
CROSBY, Katherine [US/US]; US (UsOnly)
ZENG, Qingfu [CN/US]; US (UsOnly)
LEE, Kimberly [US/US]; US (UsOnly)
Inventors:
RIKOVA, Klarisa; US
POLAKIEWICZ, Roberto; US
GUO, Ailan; US
CROSBY, Katherine; US
ZENG, Qingfu; US
LEE, Kimberly; US
Agent:
CULLEM, James, Gregory; Intellectual Property Counsel Cell Signaling Technology, Inc. 166B Cummings Center Beverly, MA 01915, US
Priority Data:
11/174,05101.07.2005US
Title (EN) IDENTIFICATION OF NON-SMALL CELL LUNG CARCINOMA (NSCLC) TUMORS EXPRESSING PDGFR-ALPHA
(FR) IDENTIFICATION DES TUMEURS DU CANCER BRONCHOPULMONAIRE 'NON A PETITES CELLULES'' (NSCLC) EXPRIMANT PDGFR-ALPHA
Abstract:
(EN) The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFR&agr;) is expressed and is driving the disease, and provided methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFR&agr; is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFR&agr;-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFR&agr; is expressed, and for determining whether a compound inhibits the progression of a PDGFR&agr;-expressing mammalian NSCLC tumor.
(FR) La présente invention concerne un sous-ensemble jusqu'alors non identifié de carcinomes bronchopulmonaires 'non à petites cellules'' de mammifère (NSCLC) dans lequel le récepteur alpha du facteur de croissance dérivé des plaquettes (PDGFRa) est exprimé et commande la maladie ainsi que des méthodes permettant d'identifier une tumeur NSCLC de mammifère qui appartient à un sous-ensemble de tumeurs NSCLC dans lequel PDGFRa est exprimé et permettant d'identifier une tumeur NSCLC qui est susceptible de réagir à une thérapie inhibant PDGFRa. Cette invention porte également sur des méthodes permettant d'inhiber l'évolution d'une tumeur NSCLC de mammifère dans laquelle PDGFRa est exprimé et de déterminer si un composé inhibe l'évolution d'un tumeur NSCLC de mammifère dans laquelle est exprimé PDGFRa.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020080030648EP1907842CN101322031CA2617201KR1020130001342DK1907842
AU2005334101