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1. (WO2007004979) METHOD FOR MODULATING RESPONSIVENESS TO STEROIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004979 International Application No.: PCT/SE2006/050232
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
A61K 38/00 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
INDEX PHARMACEUTICALS AB [SE/SE]; Scheeles Väg 1 S-171 77 Stockholm, SE (AllExceptUS)
SPIIK, Ann-Kristin [SE/SE]; SE (UsOnly)
LÖFBERG, Robert [SE/SE]; SE (UsOnly)
BANDHOLTZ, Lisa, Charlotta [SE/SE]; SE (UsOnly)
VON STEIN, Oliver [SE/SE]; SE (UsOnly)
Inventors:
SPIIK, Ann-Kristin; SE
LÖFBERG, Robert; SE
BANDHOLTZ, Lisa, Charlotta; SE
VON STEIN, Oliver; SE
Agent:
BERGENSTRÅHLE & LINDVALL AB; Box 17704 S-118 93 Stockholm, SE
Priority Data:
60/696,05001.07.2005US
Title (EN) METHOD FOR MODULATING RESPONSIVENESS TO STEROIDS
(FR) METHODE DE MODULATION DE LA REPONSE AUX STEROIDES
Abstract:
(EN) The present invention makes it possible to enhance steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an effective amount of an oligonucleotide having the sequence 5'-Xm-TTCGT-Yn-3' to 5 said patient, wherein X is A, T, C or G, Y is A, T, C or G, m=0-7, n=0-7 and wherein at least one CG dinucleotide is unmethylated. The invention also encompasses the use of said oligonucleotide for the manufacture of pharmaceuticals.
(FR) La présente invention concerne l'amélioration de l'efficacité des stéroïdes chez un patient réfractaire aux stéroïdes souffrant d'un état inflammatoire ne répondant pas ou peu ou de manière inadéquate à un traitement anti-inflammatoire, par administration d'une quantité efficace d'un oligonucléotide présentant la séquence 5'-Xm-TTCGT-Yn-3' à 5 audit patient, dans laquelle X est A, T, C ou G, Y est A, T, C ou G, m=0-7, n=0-7, et au moins un dinucléotide CG est non méthylé. L'invention concerne également l'utilisation dudit oligonucléotide dans la fabrication de produits pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2179737EP1904077JP2008544984US20080318885JP2012193192