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1. (WO2007004954) [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELCTIVE ADSORPTION OF IGG
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/004954    International Application No.:    PCT/SE2006/000808
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
C07D 487/04 (2006.01), B01D 15/38 (2006.01), B01J 20/289 (2006.01)
Applicants: GE HEALTHCARE BIO-SCIENCES AB [SE/SE]; Patent Department, Björkgatan 30, S-751 84 Uppsala (SE) (For All Designated States Except US).
ALTERMAN, Mathias [SE/SE]; (SE) (For US Only).
AXÉN, Andreas [SE/SE]; (SE) (For US Only).
CARREDANO, Enrique [SE/SE]; (SE) (For US Only).
GRÖNBERG, Anna [SE/SE]; (SE) (For US Only).
ZOU, Jinyu [SE/SE]; (SE) (For US Only)
Inventors: ALTERMAN, Mathias; (SE).
AXÉN, Andreas; (SE).
CARREDANO, Enrique; (SE).
GRÖNBERG, Anna; (SE).
ZOU, Jinyu; (SE)
Agent: GE HEALTHCARE BIO-SCIENCES AB; Patent Department, Björkgatan 30, S-751 84 Uppsala (SE)
Priority Data:
0501560-7 05.07.2005 SE
Title (EN) [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELCTIVE ADSORPTION OF IGG
(FR) DERIVES DE [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE UTILISES COMME ADSORBANTS CHROMATOGRAPHIQUES D'ADSORPTION SELECTIVE D'IGG
Abstract: front page image
(EN)The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula (I) and its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, -C(O)NHR3, -C(O)-R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
(FR)La présente invention concerne un adsorbant chromatographique d'adsorption sélective d'IgG, comprenant la formule suivante (I) et sa forme énol correspondante, dans laquelle X représente O, S, ou NH; R1 représente H, C1-6 alkyle, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyle, Ar, -C(O)NHR3, -C(O)-R3 ou halo; R2 représente H, C1-3 alkyle ou halo; R3 représente H, C1-6 alkyle, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyle ou Ar; n représente 0, 1, 2 ou 3; et Y représente un support. La présente invention concerne également une méthode de production dudit adorbant, ainsi que l'utilisation de celui-ci dans la séparation de substances par chromatographie d'affinité.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)