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1. (WO2007004748) NUCLEIC ACID CAPABLE OF BINDING TO IMMUNOGLOBULIN G AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004748 International Application No.: PCT/JP2006/313811
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
C12N 15/09 (2006.01) ,C07K 1/22 (2006.01) ,G01N 33/543 (2006.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
22
Affinity chromatography or related techniques based upon selective absorption processes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
株式会社リボミック RIBOMIC Inc. [JP/JP]; 〒1080001 東京都港区白金台三丁目15番5号 Tokyo 16-13,Shirokanedai 3-chome, Minato-ku, Tokyo 1080071, JP (AllExceptUS)
中村 義一 NAKAMURA, Yoshikazu [JP/JP]; JP (UsOnly)
宮川 伸 MIYAKAWA, Shin [JP/JP]; JP (UsOnly)
Inventors:
中村 義一 NAKAMURA, Yoshikazu; JP
宮川 伸 MIYAKAWA, Shin; JP
Agent:
高島 一 TAKASHIMA, Hajime; 〒5410044 大阪府大阪市中央区伏見町四丁目1番1号 明治安田生命大阪御堂筋ビル Osaka Meiji Yasuda Seimei Osaka Midosuji Bldg. 1-1, Fushimimachi 4-chome Chuo-ku, Osaka-shi Osaka 5410044, JP
Priority Data:
2005-19571705.07.2005JP
60/749,02612.12.2005US
Title (EN) NUCLEIC ACID CAPABLE OF BINDING TO IMMUNOGLOBULIN G AND USE THEREOF
(FR) ACIDE NUCLÉIQUE CAPABLE DE SE LIER À UNE IMMUNOGLOBULINE G ET SON UTILISATION
(JA) 免疫グロブリンGに結合する核酸とその利用法
Abstract:
(EN) A novel aptamer against IgG, use of the aptamer and others. More specifically, an aptamer capable of binding to the Fc segment of IgG (e.g., human IgG); a complex comprising the aptamer and a functional substance bound to the aptamer (e.g., an affinity substance, a labeling substance, an enzyme, a medicinal substance, a toxin, a drug delivery medium); a solid support having the aptamer or the complex immobilized thereto; a device for medical purposes comprising the solid support; a method for purification of an antibody, comprising holding an IgG antibody by adsorption on the solid support and eluting the adsorbed IgG antibody with an eluent; a process for producing a purified antibody, comprising preparing an IgG antibody and purifying the IgG antibody using the solid support; and others.
(FR) L'invention concerne, entre autres, un nouvel aptamère contre les IgG, son utilisation. Plus spécifiquement, elle concerne un nouvel aptamère capable de se lier au segment Fc d'une IgG (par exemple une IgG humaine) ; un complexe comprenant, entre autres, l'aptamère et une substance fonctionnelle liée à l'aptamère (par exemple une substance d'affinité, de marquage, une enzyme, une substance médicinale, une toxine, un milieu d'administration médicamenteuse) ; un support solide ayant l'aptamère ou le complexe immobilisé sur celui-ci ; un dispositif à des fins médicales comprenant ce support solide ; un procédé de purification d'un anticorps, comprenant le maintien d'un anticorps IgG par adsorption sur le support solide et l'élution de l'anticorps adsorbé avec un éluant ; un processus de production d'un anticorps purifié, comprenant la préparation d'un anticorps IgG et sa purification en utilisant le support solide .
(JA) 本発明は、IgGに対する新規アプタマー及びその利用方法などを提供する。より詳細には、本発明は、IgG(例、ヒトIgG)のFc部分に対して結合するアプタマー;アプタマー及びそれに結合した機能性物質(例、親和性物質、標識用物質、酵素、薬物、毒素、薬物送達媒体)を含む複合体;アプタマー又は複合体が固定化された固相担体;固相担体を含む医療用機器;固相担体にIgG抗体を吸着させ、吸着したIgG抗体を溶出液により溶出させることを含む、抗体精製方法;IgG抗体を作製し、作製されたIgG抗体を固相担体により精製することを含む、精製抗体の製造方法などを提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020080036595EP1918372US20090170219CN101258241CA2614145JP4910195
IN490/KOLNP/2008