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1. (WO2007004705) GLYCOLIPID DERIVATIVE AND THERAPEUTIC AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004705 International Application No.: PCT/JP2006/313519
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07D 309/10 (2006.01) ,A61K 31/351 (2006.01) ,A61K 31/7032 (2006.01) ,A61P 37/02 (2006.01) ,A61P 37/08 (2006.01) ,C07H 15/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02
having no double bonds between ring members or between ring members and non-ring members
08
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10
Oxygen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
351
not condensed with another ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7032
attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
Applicants:
国立精神・神経センター総長が代表する日本国 Japan as represented by President of National Center of Neurology and Psychiatry [JP/JP]; 〒1878551 東京都小平市小川東町四丁目1番1号 Tokyo 1-1, Ogawahigashicho 4-chome, Kodaira-shi, Tokyo 1878551, JP (AllExceptUS)
第一アスビオファーマ株式会社 ASUBIO PHARMA CO., LTD. [JP/JP]; 〒1078541 東京都港区赤坂二丁目9番11号 Tokyo 9-11, Akasaka 2-chome, Minato-ku, Tokyo 1078541, JP (AllExceptUS)
三宅 幸子 MIYAKE, Sachiko [JP/JP]; JP (UsOnly)
山村 隆 YAMAMURA, Takashi [JP/JP]; JP (UsOnly)
鳥羽 哲也 TOBA, Tetsuya [JP/JP]; JP (UsOnly)
Inventors:
三宅 幸子 MIYAKE, Sachiko; JP
山村 隆 YAMAMURA, Takashi; JP
鳥羽 哲也 TOBA, Tetsuya; JP
Agent:
青木 篤 AOKI, Atsushi; 〒1058423 東京都港区虎ノ門三丁目5番1号 虎ノ門37森ビル 青和特許法律事務所 Tokyo SEIWA PATENT & LAW Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chome Minato-ku, Tokyo 105-8423, JP
Priority Data:
2005-19411601.07.2005JP
2005-26571613.09.2005JP
Title (EN) GLYCOLIPID DERIVATIVE AND THERAPEUTIC AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT
(FR) DÉRIVÉ GLYCOLIPIDIQUE ET AGENT THÉRAPEUTIQUE COMPRENANT CE DÉRIVÉ EN TANT QUE MATIÈRE ACTIVE
(JA) 糖脂質誘導体及びそれを有効成分とする治療剤
Abstract:
(EN) A glycolipid derivative represented by the formula (I): (I) wherein R1 represents an aldopyranaose residue, R2 represents a hydrogen atom or a hydroxyl group, A represents -CH2-,-CH(OH)-CH2- or -CH=CHCH2-, Z represents -O- or -CH2-, and y represents an integer of 26 to 35 when Z represents -O- and x represents an integer of 4 to 16, y represents an integer of 0 to 35 when Z represents -O- and x represents an integer of 17 to 25, y represents an integer of 26 to 35 when Z represents -CH2- and x represents an integer of 4 to 15 and y represents an integer of 0 to 35 when Z represents -CH2- and x represents an integer of 16 to 25; and a therapeutic agent for an autoimmune disease (e.g., autoimmune arthritis), an allergic disease (e.g., bronchial asthma) or a disease of which an NKT cell or the stimulation of an NKT cell is known to be involved in the aggravation of the condition comprising the glycolipid derivative.
(FR) La présente invention concerne un dérivé glycolipidique représenté par la formule (I) : (I) dans laquelle R1 représente un résidu aldopyranose, R2 représente un atome d'hydrogène ou un groupe hydroxyle, A représente -CH2-,-CH(OH)-CH2- ou -CH=CHCH2-, Z représente -O- ou -CH2- et y représente un nombre entier de 26 à 35 quand Z représente -O- et x représente un nombre entier de 4 à 16, y représente un nombre entier de 0 à 35 quand Z représente -O- et x représente un nombre entier de 17 à 25, y représente un nombre entier de 26 à 35 quand Z représente -CH2- et x représente un nombre entier de 4 à 15 et y représente un nombre entier de 0 à 35 quand Z représente -CH2- et x représente un nombre entier de 16 à 25. La présente invention concerne également un agent thérapeutique comprenant le dérivé glycolipidique et destiné au traitement d'une maladie auto-immune (par exemple l'arthrite auto-immune), d'une maladie allergique (par exemple l'asthme bronchique) ou d'une maladie dont on sait qu'elle met en jeu une cellule NKT ou la stimulation d'une cellule NKT dans l'aggravation de l'état.
(JA) 式(I): (式中、R1はアルドピラノース残基を示し、R2は水素原子又は水酸基を示し、Aは−CH2−、−CH(OH)−CH2−又は−CH=CHCH2−を示し、Zは−O−又は-CH2-を示し、Zが−O−で、xが4~16の整数を示す場合、yは26~35の整数を示し、Zが−O−で、xが17~25の整数を示す場合、yは0~35の整数を示し、Zが−CH2−でxが4~15の整数を示す場合、yは26~35の整数を示し、Zが−CH2−でxが16~25の整数を示す場合、yは0~35の整数を示す)で表される糖脂質誘導体及びそれらを含有する自己免疫性関節炎等の自己免疫疾患、気管支喘息等のアレルギー疾患或いはNKT細胞或いはNKT細胞への刺激が病態悪化に関与することが知られている疾患の治療薬。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020080021761EP1905766US20090227781CN101233124CA2613350IN10121/DELNP/2007