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1. (WO2007004635) METHOD FOR DIFFERENTIATION CULTURE OF PREADIPOCYTE INTO ADIPOCYTE BY COCULTURE WITH MACROPHAGE, AND SCREENING OF SUBSTANCE CAPABLE OF AFFECTING THE DIFFERENTIATION PROCESS OF PREADIPOCYTE INTO ADIPOCYTE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004635 International Application No.: PCT/JP2006/313285
Publication Date: 11.01.2007 International Filing Date: 04.07.2006
IPC:
C12N 5/00 (2006.01) ,C12N 5/077 (2010.01) ,C12Q 1/02 (2006.01) ,C12Q 1/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Applicants:
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 〒5650871 大阪府吹田市山田丘1番1号 Osaka 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP (AllExceptUS)
松山 晃文 MATSUYAMA, Akifumi [JP/JP]; JP (UsOnly)
澤 芳樹 SAWA, Yoshiki [JP/JP]; JP (UsOnly)
金倉 譲 KANAKURA, Yuzuru [JP/JP]; JP (UsOnly)
Inventors:
松山 晃文 MATSUYAMA, Akifumi; JP
澤 芳樹 SAWA, Yoshiki; JP
金倉 譲 KANAKURA, Yuzuru; JP
Agent:
河宮 治 KAWAMIYA, Osamu; 〒5400001 大阪府大阪市中央区城見1丁目3番7号IMPビル青山特許事務所 Osaka AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001, JP
Priority Data:
2005-19526904.07.2005JP
Title (EN) METHOD FOR DIFFERENTIATION CULTURE OF PREADIPOCYTE INTO ADIPOCYTE BY COCULTURE WITH MACROPHAGE, AND SCREENING OF SUBSTANCE CAPABLE OF AFFECTING THE DIFFERENTIATION PROCESS OF PREADIPOCYTE INTO ADIPOCYTE
(FR) PROCEDE DE CULTURE POUR LA DIFFERENCIATION D'UN PREADIPOCYTE EN ADIPOCYTE PAR CO-CULTURE AVEC UN MACROPHAGE, ET CRIBLAGE D'UNE SUBSTANCE SUSCEPTIBLE D'INFLUER SUR LE PROCESSUS DE DIFFERENCIATION D'UN PREADIPOCYTE EN ADIPOCYTE
(JA) マクロファージとの共培養による脂肪前駆細胞の脂肪細胞への分化培養方法、ならびにその分化過程に影響する物質のスクリーニング
Abstract:
(EN) A culture method for inducing the differentiation of a preadipocyte into an adipocyte, the method comprising co-cultivating the preadipocyte with a macrophage in a culture medium free from PPAR-ϝ agonist and IBMX; an adipocyte produced by the culture method; a screening method for a substance capable of affecting the differentiation process of a preadipocyte into an adipocyte, characterized by using the culture method; a substance capable of affecting the differentiation process of a preadipocyte into an adipocyte, the substance being given by the screening method; a kit for the screening; and others.
(FR) La présente invention concerne un procédé de culture pour induire la différenciation d'un préadipocyte en un adipocyte, le procédé comprenant la co-culture du préadipocyte avec un macrophage dans un milieu de culture exempt d'agoniste de PPAR-ϝ et d'IBMX ; un adipocyte produit grâce au procédé de culture ; un procédé de criblage pour une substance susceptible d'influer sur le processus de différenciation d'un préadipocyte en un adipocyte, caractérisé par l'utilisation du procédé de culture ; une substance susceptible d'influer sur le processus de différenciation d'un préadipocyte en un adipocyte, la substance étant obtenue grâce au procédé de criblage ; un kit pour le criblage ; et autres.
(JA)  本発明は、PPAR-γアゴニストおよびIBMXを含まない培地中で脂肪前駆細胞をマクロファージと共培養することを特徴とする、脂肪前駆細胞を脂肪細胞に分化させる培養方法およびそれにより得ることのできる脂肪細胞、かかる培養方法を用いることを特徴とする、脂肪前駆細胞から脂肪細胞への分化過程に影響する物質をスクリーニングする方法およびそれにより得ることのできる脂肪前駆細胞から脂肪細胞への分化過程に影響する物質、ならびにかかるスクリーニングのためのキットなどを提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)