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1. (WO2007004613) THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-&agr; PRODUCTION INHIBITOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004613 International Application No.: PCT/JP2006/313236
Publication Date: 11.01.2007 International Filing Date: 03.07.2006
IPC:
A61K 31/198 (2006.01) ,A61K 31/405 (2006.01) ,A61K 31/4172 (2006.01) ,A61P 1/00 (2006.01) ,A61P 1/04 (2006.01) ,A61P 37/02 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4172
Imidazole-alkanecarboxylic acids, e.g. histidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
04
for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
味の素株式会社 AJINOMOTO CO., INC. [JP/JP]; 〒1048315 東京都中央区京橋1丁目15番1号 Tokyo 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315, JP (AllExceptUS)
松本 英希 MATSUMOTO, Hideki [JP/JP]; JP (UsOnly)
奥津 倫久 OKUTSU, Tomohisa [JP/JP]; JP (UsOnly)
武田 智子 TAKEDA, Tomoko [JP/JP]; JP (UsOnly)
鈴木 秀樹 SUZUKI, Hideki [JP/JP]; JP (UsOnly)
矢野 徹雄 YANO, Tetsuo [JP/JP]; JP (UsOnly)
橋本 雅棋 HASHIMOTO, Masaki [JP/JP]; JP (UsOnly)
小野 美保 ONO, Miho [JP/JP]; JP (UsOnly)
鈴木 学 SUZUKI, Manabu [JP/JP]; JP (UsOnly)
Inventors:
松本 英希 MATSUMOTO, Hideki; JP
奥津 倫久 OKUTSU, Tomohisa; JP
武田 智子 TAKEDA, Tomoko; JP
鈴木 秀樹 SUZUKI, Hideki; JP
矢野 徹雄 YANO, Tetsuo; JP
橋本 雅棋 HASHIMOTO, Masaki; JP
小野 美保 ONO, Miho; JP
鈴木 学 SUZUKI, Manabu; JP
Agent:
熊倉 禎男 KUMAKURA, Yoshio; 〒1008355 東京都千代田区丸の内3丁目3番1号 新東京ビル 中村合同特許法律事務所 Tokyo NAKAMURA & PARTNERS Shin-Tokyo Bldg. 3-1, Marunouchi 3-chome Chiyoda-ku Tokyo1008355, JP
Priority Data:
2005-19359101.07.2005JP
Title (EN) THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-&agr; PRODUCTION INHIBITOR
(FR) AGENT THÉRAPEUTIQUE CONTRE L'AFFECTION ABDOMINALE INFLAMMATOIRE ET INHIBITEUR DE LA PRODUCTION DE TNF-&Agr;
(JA) 炎症性腸疾患治療薬及びTNF-α産生抑制剤
Abstract:
(EN) Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-&agr;. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-&agr; production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.
(FR) L'invention concerne un agent destiné à être utilisé dans le traitement ou la prévention de l'affection abdominale inflammatoire. Elle concerne aussi un agent inhibant la production de TNF-&agr;. Elle présente un agent thérapeutique ou prophylactique pour cette affection abdominale inflammatoire comprenant au moins un acide aminé choisi dans le groupe constitué de la lysine, l'histidine, la phénylalanine, la méthionine, le tryptophane, la glutamine, la glycine, la cystéine, la cystine et la thréonine, l'acide aminé étant administré à une dose de 0,1 à 4000 mg/kg par jour ; et un inhibiteur de la production de TNF-&agr; comprenant un acide aminé choisi dans le groupe constitué de l'histidine, la phénylalanine et le tryptophane, l'acide aminé étant administré à une dose de 0,1 à 4000 mg/kg par jour.
(JA)  本発明は炎症性腸疾患の治療又は予防に用いる薬剤を提供することを目的とする。また、本発明はTNF-αの産生を抑制する薬剤を提供することを目的とする。 本発明は、リジン、ヒスチジン、フェニルアラニン、メチオニン、トリプトファン、グルタミン、グリシン、システイン、シスチン及びスレオニンからなる群より選ばれる1種以上のアミノ酸を含有し、前記アミノ酸が1日当たり0.1~4000mg/kgの量にて投与されることを特徴とする炎症性腸疾患治療又は予防薬を提供する。また、本発明は、ヒスチジン、フェニルアラニン及びトリプトファンからなる群より選ばれるアミノ酸を含有し、前記アミノ酸が1日当たり0.1~4000mg/kgの量にて投与されることを特徴とするTNF-α産生抑制剤を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP1920770JPWO2007004613US20080108684