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1. (WO2007004510) PHARMACEUTICAL FOR USE IN THE TREATMENT OF CEREBRAL INFARCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004510 International Application No.: PCT/JP2006/312996
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
A61K 31/5375 (2006.01) ,A61K 38/48 (2006.01) ,A61K 45/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 25/00 (2006.01) ,C07D 295/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
12
substituted by singly or doubly bound nitrogen atoms
Applicants:
大正製薬株式会社 TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 〒1708633 東京都豊島区高田3丁目24番1号 Tokyo 24-1, Takada 3-chome, Toshima-ku, Tokyo 1708633, JP (AllExceptUS)
大村 知広 OMURA, Tomohiro [JP/JP]; JP (UsOnly)
宮田 則之 MIYATA, Noriyuki [JP/JP]; JP (UsOnly)
奥山 茂 OKUYAMA, Shigeru [JP/JP]; JP (UsOnly)
Inventors:
大村 知広 OMURA, Tomohiro; JP
宮田 則之 MIYATA, Noriyuki; JP
奥山 茂 OKUYAMA, Shigeru; JP
Agent:
浅村 皓 ASAMURA, Kiyoshi; 〒1000004 東京都千代田区大手町2丁目2番1号 新大手町ビル331 Tokyo Room 331, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004, JP
Priority Data:
2005-19098530.06.2005JP
Title (EN) PHARMACEUTICAL FOR USE IN THE TREATMENT OF CEREBRAL INFARCTION
(FR) MÉDICAMENT POUR LE TRAITEMENT D'UN INFARCTUS CÉRÉBRAL
(JA) 脳梗塞治療用の医薬
Abstract:
(EN) Disclosed is a pharmaceutical which has an excellent therapeutic effect on cerebral infarction and an excellent ameliorating effect on a dysfunction or neurologic deficit induced by cerebral infarction and produces little adverse side effects. A pharmaceutical comprising a combination of N-(3-chloro-4-morpholin-4-yl)phenyl-N’- hydroxyimidoformamide with a thrombolytic agent such as urokinase, alteplase, desmoteplase, tisokinase, nasaruplase, nateplase, pamiteplase, monteplase or batroxobin.
(FR) La présente invention décrit un médicament dont l'effet thérapeutique sur l'infarctus cérébral est excellent et dont l'effet soulageant sur un dysfonctionnement ou un déficit neurologique induit par un infarctus cérébral est également excellent, ledit médicament ne présentant que des effets secondaires restreints. La présente invention décrit notamment un médicament comprenant une combinaison de N-(3-chloro-4-morpholin-4-yl)phényl-N’-hydroxyimidoformamide et d'un agent thrombolytique tel que l’urokinase, l’altéplase, la desmotéplase, la tisokinase, la nasaruplase, la natéplase, la pamitéplase, la montéplase ou la batroxobine.
(JA)  脳梗塞治療、又は脳梗塞に起因する機能不全もしくは神経脱落症状の改善に優れ、且つ、副作用の少ない医薬を提供する。  N-(3-クロロ-4-モルホリン-4-イル)フェニル-N’-ヒドロキシイミドホルムアミドと、ウロキナーゼ、アルテプラーゼ、デスモテプラーゼ、チソキナーゼ、ナサルプラーゼ、ナテプラーゼ、パミナプラーゼ、モンテプラーゼまたはパトロキソビンなどの血栓溶解薬とを組み合わせてなる医薬とする。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)