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1. (WO2007004341) RNA-BINDING PEPTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/004341    International Application No.:    PCT/JP2006/305479
Publication Date: 11.01.2007 International Filing Date: 14.03.2006
IPC:
C12N 15/09 (2006.01), A61K 38/00 (2006.01), A61P 31/04 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01), C07K 7/08 (2006.01), C07K 14/00 (2006.01), C12N 1/15 (2006.01), C12N 1/19 (2006.01), C12N 1/21 (2006.01), C12N 5/10 (2006.01), C12Q 1/68 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: SHINKA SOYAKU INC. [JP/JP]; 213-2, Mineokacho 2-chome Hodogaya-ku, Yokohama-shi Kanagawa 240-0064 (JP) (For All Designated States Except US).
ISHIBASHI, Masaya [JP/JP]; (JP) (For US Only).
HARADA, Kazuo [JP/JP]; (JP) (For US Only).
HORIYA, Satoru [JP/JP]; (JP) (For US Only).
MATSUFUJI, Senya [JP/JP]; (JP) (For US Only)
Inventors: ISHIBASHI, Masaya; (JP).
HARADA, Kazuo; (JP).
HORIYA, Satoru; (JP).
MATSUFUJI, Senya; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA Fukuoka Bldg., 9th Fl. 8-7, Yaesu 2-chome Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2005-194308 01.07.2005 JP
Title (EN) RNA-BINDING PEPTIDE
(FR) PEPTIDE SE LIANT A L'ARN
(JA) RNA結合ペプチド
Abstract: front page image
(EN)An RNA-binding peptide capable of binding to a nucleotide sequence depicted by GNRA in GNRA-containing RNA, such as a peptide comprising an amino acid sequence depicted by the formula I or a derivative thereof or a salt of the peptide or derivative: Gly-Gly-X1-X2-Ala-Arg-X3-Arg-Arg-X4-X5-Arg-Arg (I) wherein X1 represents Arg or Lys; X2 represents an arbitrary amino acid residue; X3 represents Ala or Arg; X4 represents Ala or Arg; and X5 represents an arbitrary amino acid residue.
(FR)La présente invention concerne un peptide se liant à l'ARN, susceptible de se lier à une séquence nucléotidique représentée par GNRA dans un ARN contenant un motif GNRA, tel qu'un peptide comprenant une séquence d'acides aminés représentée par la formule I ou un derivé de celui-ci ou un sel du peptide ou du dérivé : Gly-Gly-X1-X2-Ala-Arg-X3-Arg-Arg-X4-X5-Arg-Arg (I) où X1 représente Arg ou Lys; X2 représente un résidu d'acide aminé arbitraire; X3 représente Ala ou Arg; X4 représente Ala ou Arg; et X5 représente un résidu d'acide aminé arbitraire.
(JA)本発明は、GNRAで示される塩基配列を含むRNAのうち当該GNRA配列への結合活性を有するRNA結合ペプチド、例えば、次式I:Gly-Gly-X1-X2-Ala-Arg-X3-Arg-Arg-X4-X5-Arg-Arg (I)(X1はArg又はLysを表し、X2は任意のアミノ酸残基を表し、X3はAla又はArgを表し、X4はAla又はArgを表し、X5は任意のアミノ酸残基を表す。)で示されるアミノ酸配列を含むペプチド、その誘導体又はこれらの塩を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)