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1. (WO2007004239) NEW POLYMORPHIC FORM OF SULTAMICILLIN TOSYLATE AND A PROCESS THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/004239    International Application No.:    PCT/IN2006/000234
Publication Date: 11.01.2007 International Filing Date: 04.07.2006
IPC:
C07D 499/68 (2006.01), A61P 31/04 (2006.01), A61K 31/43 (2006.01)
Applicants: MOREPEN LABORATORIES LIMITED [IN/IN]; Village Masulkhana, District Solan, Parwanoo 173 220, Himachal Pradesh (IN) (For All Designated States Except US).
SURI, Sanjay [IN/IN]; (IN) (For US Only).
KASHYAP, Tapan [IN/IN]; (IN) (For US Only).
SINGH, Netar [IN/IN]; (IN) (For US Only)
Inventors: SURI, Sanjay; (IN).
KASHYAP, Tapan; (IN).
SINGH, Netar; (IN)
Agent: BALASUBRAHMANYAM, Lakshmi; Corporate Law Group, 1106-1107 Kailash Building, 26 K.G. Marg, New Delhi 110 001 (IN)
Priority Data:
1755/DEL/2005 06.07.2005 IN
Title (EN) NEW POLYMORPHIC FORM OF SULTAMICILLIN TOSYLATE AND A PROCESS THEREFOR
(FR) NOUVELLE FORME POLYMORPHIQUE DU TOSYLATE DE SULTAMICILLINE ET PROCEDE CORRESPONDANT
Abstract: front page image
(EN)This invention provides crystalline polymorphic form 2 of VD 1827 tosylate characterized by the following infra red spectrum pattern: 2978, 1793, 1689, 1498, 1459, 1326, 1175, 1126, 1009, 975, 684, 570 (± 5 cm-1) The invention is further characterized by the following XRD pattern expressed in terms of '2 Theta' and 'd' spacing (± 0.5) 14.78, 15.92, 19.34, 20.70. The invention is further characterized by the following DSC pattern: Onset 174.73°C, End set 179.76 °C, Peak 177.52 °C (± 5°C) Melting range: 160- 175 °C. Form 2 has dissolution profile as in table (1). The said Form 2 is prepared by synthesizing Sultamicillin tosylate pure/recrystallised according to US patent no. 4,342,772, dissolving the compound obtained in step (a) in a polar organic solvent crystallizing Form 2 from the reaction mass followed by filtration and drying.
(FR)La présente invention concerne une forme 2 polymorphique cristalline de tosylate VD 1827 qui se caractérise par le motif de spectre infrarouge suivant: 2978, 1793, 1689, 1498, 1459, 1326, 1175, 1126, 1009, 975, 684, 570 (± 5 cm-1). Cette invention se caractérise également par le profil XRD suivant exprimé en termes de 'Theta 2' et d'espacement 'd' (± 0,5): 14,78, 15,92, 19,34, 20,70. Cette invention se caractérise en outre par le profil DSC suivant: température de départ: 174,73 °C, température finale: 179,76 °C, crête à 177,52 °C (± 5°C), et gamme de fusion comprise entre 160 et 175 °C. La forme 2 présente le profil de dissolution donné dans le tableau (1). La forme 2 est préparée selon un procédé consistant à synthétiser le tosylate de sultamicilline pur/recristallisé conformément au brevet américain US 4,342,772, à dissoudre le composé obtenu à l'étape (a) dans un solvant organique polaire, à cristalliser la forme 2 à partir de la masse de réaction, après quoi interviennent la filtration et le séchage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)