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1. (WO2007004170) PRODUCTION OF SECONDARY METABOLITES USING CAPILLARY MEMBRANES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/004170 International Application No.: PCT/IB2006/052201
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
Chapter 2 Demand Filed: 26.07.2007
IPC:
C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
SYNEXA LIFE SCIENCES (PROPRIETARY) LIMITED [ZA/ZA]; 3 Ebony Road, Bellville 7530 Cape Town, ZA (AllExceptUS)
LEUKES, Winston, Daniel [ZA/ZA]; ZA (UsOnly)
FRASER, Sheena, Janet [ZA/ZA]; ZA (UsOnly)
EDWARDS, Wade [ZA/ZA]; ZA (UsOnly)
Inventors:
LEUKES, Winston, Daniel; ZA
FRASER, Sheena, Janet; ZA
EDWARDS, Wade; ZA
Agent:
HEATHER, Donald; Spoor & Fisher P.O. Box 454 0001 Pretoria, ZA
Priority Data:
2005/0531530.06.2005ZA
Title (EN) PRODUCTION OF SECONDARY METABOLITES USING CAPILLARY MEMBRANES
(FR) PRODUCTION DE METABOLITES SECONDAIRES OU DE PRODUITS RECOMBINES
Abstract:
(EN) The invention provides methods of producing secondary metabolites and under recombinant products oxygen-limited or anaerobic culture conditions. The methods include providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, and causing a nutrient solution to flow through the biofilm and the substrate in a direction from the first side thereof to the second side thereof under oxygen-limited or anaerobic culture conditions. The microorganisms include Clostridium sp., Bacillus sp., Pseudomonas sp. Vibrio sp., Serratia sp., Rhodopseudomonas sp., Anaeromyxobacter sp., Desulphovibrio sp., and Candida sp., Lactococcus lactis, Escherichia coli, Bacillus subtillus, Pichia sp., Candida sp., Hansenula polymorpha and Sacharomyces cerevisiae.
(FR) L'invention concerne des procédés permettant de produire des métabolites secondaires et/ou des produits recombinés dans des conditions de culture pauvres en oxygène ou anaérobies. Ces procédés consistent à prendre un substrat poreux qui présente un premier et un second côté, et qui comprend un film biologique de micro-organismes fixé sur le premier côté, et à faire circuler une solution nutritive à travers le film biologique et le substrat, du premier côté en direction du second côté, dans des conditions de culture pauvres en oxygène ou anaérobies. Les micro-organismes utilisés comprennent Clostridium sp., Bacillus sp., Pseudomonas sp. Vibrio sp., Serratia sp., Rhodopseudomonas sp., Anaeromyxobacter sp., Desulphovibrio sp., et Candida sp., Lactococcus lactis, Escherichia coli, Bacillus subtillus, Pichia sp., Candida sp., Hansenula polymorpha et Sacharomyces cerevisiae.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1907542ZA2008/00356US20100159555ES2396654CN101233234CA2613237
IN10032/DELNP/2007