WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007004060) CYTOKINE RECEPTOR MODULATORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/004060    International Application No.:    PCT/IB2006/002298
Publication Date: 11.01.2007 International Filing Date: 05.05.2006
IPC:
C12N 15/18 (2006.01), A61P 27/02 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 9/10 (2006.01), C07K 7/06 (2006.01), C12N 15/11 (2006.01), G01N 33/566 (2006.01), C07K 14/52 (2006.01)
Applicants: VALORISATION HSJ, SOCIETE EN COMMANDITE [CA/CA]; 5160, Boulevard Decarie, Bureau 770, Montreal, Quebec, H3X 2H9 (CA) (For All Designated States Except US).
CHEMTOB, Sylvain [CA/CA]; (CA) (For US Only).
QUINIOU, Christiane [CA/CA]; (CA) (For US Only).
BEAUCHAMP, Martin [CA/CA]; (CA) (For US Only)
Inventors: CHEMTOB, Sylvain; (CA).
QUINIOU, Christiane; (CA).
BEAUCHAMP, Martin; (CA)
Agent: ROBINSON, J., Christopher; Smart & Biggar, Box 11560, Vancouver Centre, 650 West Georgia Street, Suite 2200, Vancouver, British Columbia V6B 4N8 (CA)
Priority Data:
PCT/CA2005/000691 05.05.2005 CA
60/751,360 16.12.2005 US
Title (EN) CYTOKINE RECEPTOR MODULATORS AND USES THEREOF
(FR) MODULATEURS DU RECEPTEUR DE LA CYTOKINE ET LEURS UTILISATIONS
Abstract: front page image
(EN)Non-competitive peptide antagonists of cytokine receptors, methods of their identification and therapeutic uses thereof are disclosed, wherein said peptides are between 7 and 20 ammo acids in length and derived from the extracellular regions of the msulm-like growth factor 1 receptor, human vascular endothelial growth factor receptor, human mterleukm-1 receptor, human mterleukm-4 receptor, human epidermal growth factor receptor or the human growth hormone receptor The compounds disclosed may be used for the treatment of cytokme-associated diseases such as proliferative disorders (colon, breast, prostate and lung cancer), abnormal neovascularization and angiogenesis, age related macular degeneration and proliferative and/or inflammatory skin disorders such as psoriasis
(FR)La présente invention concerne des composés de liaison au récepteur de la cytokine, tels que des peptides non compétitifs de liaison au récepteur VEGF, au récepteur IL-I, au récepteur IL-4, ou au récepteur IGF-I et des antagonistes pétidomimétiques, ainsi que des utilisations thérapeutiques de ces composés. Les composés de l'invention peuvent être utilisés pour traiter des troubles associés à la cytokine, tels que des troubles de prolifération (par exemple le cancer du côlon, du sein, de la prostate et du poumon), la néovascularisation anormale, l'angiogenèse anormale, la dégénérescence maculaire liée à l'âge, et les problèmes de peau de prolifération et/ou inflammatoires tels que le psoriasis.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)