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1. (WO2007003963) ZOFENOPRIL CALCIUM IN POLYMORPH FORM C
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003963 International Application No.: PCT/GB2006/050179
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07D 207/16 (2006.01) ,A61K 31/401 (2006.01) ,A61P 9/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401
Proline; Derivatives thereof, e.g. captopril
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
Applicants:
Generics [UK] Limited [GB/GB]; Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG, GB (AllExceptUS)
Merck Development Center Private Limited [IN/IN]; 1 A/2, M.I.D.C. Industrial Estate Taloja, Panvel, Dist. Raigad Maharashtra 410208, IN (AllExceptUS)
GORE, Vinayak G. [IN/IN]; IN (UsOnly)
PEHERE, Ashok D. [IN/IN]; IN (UsOnly)
GAIKWAD, Avinash C. [IN/IN]; IN (UsOnly)
VIJAYKAR, Priyesh S. [IN/IN]; IN (UsOnly)
Inventors:
GORE, Vinayak G.; IN
PEHERE, Ashok D.; IN
GAIKWAD, Avinash C.; IN
VIJAYKAR, Priyesh S.; IN
Agent:
ELEND, Almut, Susanne ; Venner Shipley LLP Byron House Cambridge Business Park Cowley Road Cambridge CB4 0WZ, GB
Priority Data:
780/mum/200501.07.2005IN
Title (EN) ZOFENOPRIL CALCIUM IN POLYMORPH FORM C
(FR) ZOFÉNOPRIL CALCIUM SOUS LA FORME POLYMORPHIQUE C
Abstract:
(EN) The present invention relates to a novel crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-l-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4- (phenylthio)-L-proline calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium and its use in pharmaceutical preparations
(FR) La présente invention concerne une nouvelle forme cristalline du zofénopril calcium de formule (I), dont le nom chimique est sel de calcium de la (4S)-1-[(2S)-3-(benzoylthio)-2-méthylpropionyl]-4-(phénylthio)-L-proline. La présente invention concerne en outre un procédé de synthèse de la nouvelle forme cristalline du zofénopril calcium ainsi que son emploi dans des préparations pharmaceutiques.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1899297US20080182888CA2614193AU2006264650