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1. (WO2007003958) METHODS FOR TISSUE ENGINEERING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003958 International Application No.: PCT/GB2006/002521
Publication Date: 11.01.2007 International Filing Date: 06.07.2006
Chapter 2 Demand Filed: 04.05.2007
IPC:
A61K 38/29 (2006.01) ,A61L 27/38 (2006.01) ,C12N 5/077 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
29
Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
Applicants:
THE UNIVERSITY OF BRISTOL [GB/GB]; Senate House Tyndall Avenue Bristol BS8 1TH, GB (AllExceptUS)
HOLLANDER, Anthony, Peter [GB/GB]; GB (UsOnly)
KAFIENAH, Wa'el, Zaki [GB/GB]; GB (UsOnly)
Inventors:
HOLLANDER, Anthony, Peter; GB
KAFIENAH, Wa'el, Zaki; GB
Agent:
MCQUEEN, Andrew, Peter; Stevens Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD, GB
Priority Data:
0513777.306.07.2005GB
Title (EN) METHODS FOR TISSUE ENGINEERING
(FR) PROCEDES DE GENIE TISSULAIRE
Abstract:
(EN) The invention relates to the use of parathyroid hormone-related protein (PTHrP) in the prevention of hypertrophy in chondrogenic cells for cartilage replacement. A method for engineering three dimensional cartilage constructs from chondrogenic cells is provided, said method comprising a step of treating the chondrogenic cells or immature constructs with PTHrP to regulate hypertrophy. Also provided are: three dimensional cartilage produced by the method of the invention, and an engineered cartilage construct comprising chondrogenic cells and a bioactive scaffold capable of controlled release of PTHrP. In addition, the invention provides a method for the treatment of osteoarthritis.
(FR) L'invention concerne l'utilisation de protéine relative à l'hormone parathyroïde (PTHrP) dans la prévention de l'hypertrophie dans des cellules chondrogéniques, aux fins de remplacement du cartilage. L'invention concerne également un procédé de ingénierie destinés à des constructions de cartilage tridimensionnelles à partir de cellules chondrogéniques, ce procédé comprenant un étape consistant à traiter les cellules chondrogéniques ou des constructions immatures au moyen de PTHrP, de manière à réguler l'hypertrophie. L'invention concerne, en outre: un cartilage tridimensionnel produit au moyen du procédé selon l'invention et une construction de cartilage fabriquée comprenant des cellules chondrogéniques et un échafaudage bioactif capable de libérer de manière commandée PTHrP. De plus, l'invention concerne une méthode de traitement de l'ostéoarthrite.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1899456JP2009501008US20080318859CA2613940AU2006264645