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1. (WO2007003948) CORE 2 GLCNAC-T INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003948 International Application No.: PCT/GB2006/002500
Publication Date: 11.01.2007 International Filing Date: 06.07.2006
IPC:
A61K 31/704 (2006.01) ,A61K 31/7048 (2006.01) ,A61P 9/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
704
attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BTG INTERNATIONAL LIMITED [GB/GB]; 10 Fleet Place Limeburner Lane London EC4M 7SB, GB (AllExceptUS)
CHIBBER, Rakesh [GB/GB]; GB (UsOnly)
Inventors:
CHIBBER, Rakesh; GB
Agent:
DOLAN, Anthony, Patrick; BTG International Limited 10 Fleet Place Limeburner Lane London EC4M 7SB, GB
Priority Data:
0513888.806.07.2005GB
Title (EN) CORE 2 GLCNAC-T INHIBITORS
(FR) INHIBITEURS DE LA GLCNAC-T DE STRUCTURE NOYAU 2
Abstract:
(EN) A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GIcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GIcNAc-T of formula (I) to a patient in need thereof wherein: R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6- alkoxy or C1-6 -alkoxy- C1-6-alkyl; R2 is H, -OH or C1-6 alkoxy; S1 and S2 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof.
(FR) L'invention concerne un procédé permettant de traiter un patient nécessitant une thérapie d'un état impliquant une activité préjudiciable de l'enzyme GlcNAc-T de structure noyau 2, qui consiste à administrer au patient en question une dose thérapeutiquement efficace d'un inhibiteur de la GlcNAc-T de structure noyau 2 de la formule I, dans laquelle R1 représente H, C1-6 alkyle, C1-6 hydroxyalkyle, C1-6- alcoxy ou C1-6 -alcoxy- C1-6-alkyle; R2 représente H, -OH ou C1-6 alcoxy; S1 et S2 sont des fragments de saccharide indépendamment choisis; et Z représente un fragment stéroïde; ou un sel, éther ou ester de celui-ci pharmaceutiquement acceptable.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2008/000271EP1919486JP2009500385US20070010461US20100048496US20120142620
JP2013063993CN101257909CN102172357CA2614102AU2006264635