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1. (WO2007003947) PROCESS FOR THE SYNTHESIS OF THE ACE INHIBITOR TRANDOLAPRIL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/003947    International Application No.:    PCT/GB2006/002496
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
Chapter 2 Demand Filed:    14.06.2007    
IPC:
C07D 209/42 (2006.01)
Applicants: CIPLA LIMITED [IN/IN]; 289 Bellasis Road, Mumbai Central, Mumbai 400 008 (IN) (For All Designated States Except US).
KANKAN, Rajendra, Narayanrao [IN/IN]; (IN) (For US Only).
RAO, Dharmaraj, Ramachandra [IN/IN]; (IN) (For US Only).
PHULL, Manjinder, Singh [IN/IN]; (IN) (For US Only).
SAWANT, Ashwini [IN/IN]; (IN) (For US Only).
BIRARI, Dilip, Ramdas [IN/IN]; (IN) (For US Only).
CURTIS, Philip, Anthony [GB/GB]; (GB) (MW only)
Inventors: KANKAN, Rajendra, Narayanrao; (IN).
RAO, Dharmaraj, Ramachandra; (IN).
PHULL, Manjinder, Singh; (IN).
SAWANT, Ashwini; (IN).
BIRARI, Dilip, Ramdas; (IN)
Agent: CURTIS, Philip, Anthony; A.A. Thornton & Co., 235 High Holborn, London WC1V 7LE (GB)
Priority Data:
793-MUM-2005 05.07.2005 IN
Title (EN) PROCESS FOR THE SYNTHESIS OF THE ACE INHIBITOR TRANDOLAPRIL
(FR) PROCEDE DE SYNTHESE D'UN INHIBITEUR DE L'ENZYME DE CONVERSION DE L'ANGIOTENSINE (ECA)
Abstract: front page image
(EN)A process for the synthesis of trandolapril which comprises condensing N-[I-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride with trans octahydro-1H- indole-2-carboxylic acid in a first organic solvent comprising a water immiscible inert organic solvent and in the presence of a base, and isolating trandolapril from a second organic solvent. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride may also be condensed with (2S,3aR,7aS) octahydro-1H-indole-2-carboxyIic acid in a first organic solvent and in the presence of a base, and trandolapril isolated. There is also provided a process for the resolution of racemic trans octahydro-1H-indole-2-carboxylc acid.
(FR)L'invention porte sur un procédé de synthèse de trandolapril qui consiste à condenser N-[I-(S)-éthoxycarbonyl-3-phénylpropyl]-L-alanine N-carboxyanhydride avec l'acide trans octahydro-1H-indole-2-carboxylique dans un premier solvant organique comprenant un solvant organique inerte immiscible dans l'eau et en présence d'une base, et isoler trandolapril d'un second solvant organique. N-[1-(S)-éthoxycarbonyl-3-phénylpropyl]-L-alanine N-carboxyanhydride peut être également condensé avec l'acide (2S,3aR,7aS)octahydro-1H-indole-2-carboxyIique dans un premier solvant organique et en présence d'une base, trandolapril étant ainsi isolé. L'invention porte également sur un procédé de résolution de l'acide racémique trans octahydro-1H-indole-2-carboxylique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)