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1. (WO2007003941) MODULATION OF AUTOPHAGY BY CALPAIN INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/003941    International Application No.:    PCT/GB2006/002480
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
A61K 38/55 (2006.01), A61K 31/222 (2006.01), A61K 38/06 (2006.01), A61K 31/277 (2006.01), A61K 31/451 (2006.01), A61K 31/4422 (2006.01), A61P 25/00 (2006.01), A61P 31/00 (2006.01), G01N 33/50 (2006.01)
Applicants: CAMBRIDGE ENTERPRISE LIMITED [GB/GB]; The Old Schools, Trinity Lane, Cambridge, Cambridgeshire CB2 1TN (GB) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
RUBINSZTEIN, David [GB/GB]; (GB) (For US Only).
SARKAR, Sovan [IN/GB]; (GB) (For US Only).
WILLIAMS, Andrea [GB/GB]; (GB) (For US Only).
TTOFI, Evangelia [GB/GB]; (GB) (For US Only).
O'KANE, Cahir [IE/GB]; (GB) (For US Only).
FLOTO, Andres [GB/GB]; (GB) (For US Only)
Inventors: RUBINSZTEIN, David; (GB).
SARKAR, Sovan; (GB).
WILLIAMS, Andrea; (GB).
TTOFI, Evangelia; (GB).
O'KANE, Cahir; (GB).
FLOTO, Andres; (GB)
Agent: SUTCLIFFE, Nicholas; Mewburn Ellis LLP, York House, 23 Kingsway, London, Greater London WC2B 6HP (GB)
Priority Data:
0513851.6 06.07.2005 GB
0605009.0 13.03.2006 GB
Title (EN) MODULATION OF AUTOPHAGY BY CALPAIN INHIBITION
(FR) MODULATION DE L'AUTOPHAGIE PAR INHIBITION DE LA CALPAINE
Abstract: front page image
(EN)The present invention relates to finding that the inhibition of calpain induces autophagy in eukaryotic cells through an mTOR independent pathway. Methods and materials are provided for the treatment of diseases which are ameliorated by the induction of autophagy by inhibiting calpain such as neurodegenerative and infections diseases . Also provided are screening methods for identifying compounds which inhibit calpain and may be useful for treating such conditions .
(FR)La présente invention se rapporte à la découverte du fait que l'inhibition de la calpaïne induit l'autophagie chez les cellules eucaryotes par l'intermédiaire d'une voie mTOR indépendante. Des procédés et des substances sont proposés pour le traitement de maladies qui sont améliorées par l'induction de l'autophagie grâce à l'inhibition de la calpaïne, telles que des maladies neurodégénératives et infectieuses. Des procédés de criblage pour l'identification de composés qui inhibent la calpaïne et qui peuvent être utiles pour traiter de telles affections sont également proposés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)