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1. WO2007003746 - PROLONGED RELEASE FORMULATION OF ACTIVE PRINCIPLES HAVING A PH-DEPENDENT SOLUBILITY

Publication Number WO/2007/003746
Publication Date 11.01.2007
International Application No. PCT/FR2006/001466
International Filing Date 26.06.2006
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
24
Layered or laminated unitary dosage forms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
30
Organic coatings
36
containing carbohydrates or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A61K 9/24 (2006.01)
A61K 9/36 (2006.01)
A61K 31/437 (2006.01)
A61K 47/12 (2006.01)
CPC
A61K 31/437
A61K 9/2013
A61K 9/2054
A61K 9/209
Applicants
  • SANOFI-AVENTIS [FR/FR]; 174, avenue de France F-75013 Paris, FR (AllExceptUS)
  • ALAUX, Gérard [FR/FR]; FR (UsOnly)
  • ANDRE, Frédéric [FR/FR]; FR (UsOnly)
  • LEWIS, Gareth [GB/FR]; FR (UsOnly)
  • SERRE, Véronique [FR/FR]; FR (UsOnly)
Inventors
  • ALAUX, Gérard; FR
  • ANDRE, Frédéric; FR
  • LEWIS, Gareth; FR
  • SERRE, Véronique; FR
Agents
  • WEBER, Mathieu; Sanofi-Aventis 174, avenue de France F-75013 Paris, FR
Priority Data
050653928.06.2005FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) PROLONGED RELEASE FORMULATION OF ACTIVE PRINCIPLES HAVING A PH-DEPENDENT SOLUBILITY
(FR) FORMULATION A LIBERATION PROLONGEE DE PRINCIPES ACTIFS PRESENTANT UNE SOLUBILITE DEPENDANTE DU PH
Abstract
(EN)
The invention concerns a novel formulation for prolonged release of an active principle having a pH-dependent solubility. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises on or more acidifying agents in the form of an acid salt of an organic acid.
(FR)
L'invention concerne une nouvelle formulation pour une libération prolongée d'un principe actif présentant une solubilité dépendante du pH. La formulation de l'invention comprend un excipient matriciel à base de polymère hydrophile renfermant une dose déterminée de principe actif, et comprend également un ou plusieurs agents acidifiants sous forme d'un sel acide d'un acide organique.
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