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1. (WO2007003746) PROLONGED RELEASE FORMULATION OF ACTIVE PRINCIPLES HAVING A PH-DEPENDENT SOLUBILITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003746 International Application No.: PCT/FR2006/001466
Publication Date: 11.01.2007 International Filing Date: 26.06.2006
IPC:
A61K 9/24 (2006.01) ,A61K 9/36 (2006.01) ,A61K 31/437 (2006.01) ,A61K 47/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
24
Layered or laminated unitary dosage forms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
30
Organic coatings
36
containing carbohydrates or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
Applicants:
SANOFI-AVENTIS [FR/FR]; 174, avenue de France F-75013 Paris, FR (AllExceptUS)
ALAUX, Gérard [FR/FR]; FR (UsOnly)
ANDRE, Frédéric [FR/FR]; FR (UsOnly)
LEWIS, Gareth [GB/FR]; FR (UsOnly)
SERRE, Véronique [FR/FR]; FR (UsOnly)
Inventors:
ALAUX, Gérard; FR
ANDRE, Frédéric; FR
LEWIS, Gareth; FR
SERRE, Véronique; FR
Agent:
WEBER, Mathieu; Sanofi-Aventis 174, avenue de France F-75013 Paris, FR
Priority Data:
050653928.06.2005FR
Title (EN) PROLONGED RELEASE FORMULATION OF ACTIVE PRINCIPLES HAVING A PH-DEPENDENT SOLUBILITY
(FR) FORMULATION A LIBERATION PROLONGEE DE PRINCIPES ACTIFS PRESENTANT UNE SOLUBILITE DEPENDANTE DU PH
Abstract:
(EN) The invention concerns a novel formulation for prolonged release of an active principle having a pH-dependent solubility. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises on or more acidifying agents in the form of an acid salt of an organic acid.
(FR) L'invention concerne une nouvelle formulation pour une libération prolongée d'un principe actif présentant une solubilité dépendante du pH. La formulation de l'invention comprend un excipient matriciel à base de polymère hydrophile renfermant une dose déterminée de principe actif, et comprend également un ou plusieurs agents acidifiants sous forme d'un sel acide d'un acide organique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
DZDZP2007000723NO20080420MXMX/a/2007/016238VN16884KR1020080019023IL187901
MA29560UY0001029637PE2007-0098EP1904037DOP2006000144CR36/9567
JP2008546830US20080089936CN101217943CA2611125EA200800150TN2007000438
NZ564069FR2887455AU2006264856ID048.1512MYPI 20063017IN4684/KOLNP/2007