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1. (WO2007003596) 2,4-DIAMINO-PYRIMIDINES USED AS AURORA INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003596 International Application No.: PCT/EP2006/063736
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07D 239/48 (2006.01) ,A61K 31/505 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
48
Two nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim am Rhein, DE (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Strasse 173 55216 Ingelheim, DE (DE)
ZAHN, Stephan, Karl [DE/AT]; AT (UsOnly)
BOEHMELT, Guido [DE/AT]; AT (UsOnly)
MANTOULIDIS, Andreas [DE/AT]; DE (UsOnly)
REISER, Ulrich [DE/AT]; AT (UsOnly)
TREU, Matthias [AT/AT]; AT (UsOnly)
GUERTLER, Ulrich [DE/AT]; AT (UsOnly)
SCHOOP, Andreas [DE/DE]; DE (UsOnly)
SOLCA, Flavio [CH/AT]; AT (UsOnly)
TONTSCH-GRUNT, Ulrike [AT/AT]; AT (UsOnly)
BRUECKNER, Ralph [DE/AT]; AT (UsOnly)
REITHER, Charlotte [AT/AT]; AT (UsOnly)
HERFURTH, Lars [DE/DE]; DE (UsOnly)
KRAEMER, Oliver [DE/AT]; AT (UsOnly)
STADTMUELLER, Heinz [DE/AT]; AT (UsOnly)
ENGELHARDT, Harald [DE/AT]; AT (UsOnly)
Inventors:
ZAHN, Stephan, Karl; AT
BOEHMELT, Guido; AT
MANTOULIDIS, Andreas; DE
REISER, Ulrich; AT
TREU, Matthias; AT
GUERTLER, Ulrich; AT
SCHOOP, Andreas; DE
SOLCA, Flavio; AT
TONTSCH-GRUNT, Ulrike; AT
BRUECKNER, Ralph; AT
REITHER, Charlotte; AT
HERFURTH, Lars; DE
KRAEMER, Oliver; AT
STADTMUELLER, Heinz; AT
ENGELHARDT, Harald; AT
Agent:
HAMMANN, Heinz; CD-Patents Binger Strasse 173 55216 Ingelheim am Rhein , DE
Priority Data:
05106007.701.07.2005EP
Title (DE) 2,4-DIAMINO-PYRIMIDINE ALS AURORA INHIBITOREN
(EN) 2,4-DIAMINO-PYRIMIDINES USED AS AURORA INHIBITORS
(FR) 2,4-DIAMINO-PYRIMIDINES COMME INHIBITEURS D'AURORA
Abstract:
(DE) Die vorliegende Erfindung umfasst Verbindungen der allgemeinen Formel (I), worin R1 bis R3 wie in Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, sowie deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend genannten Eigenschaften.
(EN) The invention relates to compounds of general formula (I), in which R1 to R3 are defined as cited in claim 1. Said compounds are suitable for treating diseases that are characterised by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a medicament with the aforementioned characteristics.
(FR) La présente invention concerne des composés de formule générale (1), dans laquelle R1 à R3 sont tels que définis dans la revendication 1, lesquels composés conviennent au traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale, ainsi que leur utilisation dans la production d'un médicament possédant les propriétés susmentionnées.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
NO20076059MXMX/a/2007/015992KR1020080031362IL188452AR057423PE2007-0121
EP1902037BRPI0613096-8ZA2007/09763JP2008544972US20070032514US20110251174
CN101213179US20130281429CA2613664EA200800172PT1902037NZ565475
AU2006264958DK1902037VN17469ID048.1267MYPI 20063091TH86425
IN9112/DELNP/2007