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1. (WO2007003594) SCREENING METHODS FOR INHIBITORS OF THE METALLOPROTEASE MEPRIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003594 International Application No.: PCT/EP2006/063734
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
A61K 31/40 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/12 (2006.01) ,A61P 13/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
Applicants:
SOLVAY PHARMACEUTICALS GMBH [DE/DE]; Hans-Böckler-Allee 20 30173 Hannover, DE (AllExceptUS)
WALTHER, Thomas [DE/DE]; DE (UsOnly)
Inventors:
WALTHER, Thomas; DE
Agent:
GOSMANN, Martin ; Solvay Pharmaceuticals GmbH c/o Intellectual Property & Scientific Information Hans-Böckler-Allee 20 30173 Hannover, DE
Priority Data:
05108268.308.09.2005EP
60/696,10401.07.2005US
60/715,01508.09.2005US
Title (EN) SCREENING METHODS FOR INHIBITORS OF THE METALLOPROTEASE MEPRIN
(FR) UTILISATION DE MEPRINE DE METALLOPROTEASE ET D'INHIBITEURS DE CELLE-CI
Abstract:
(EN) Compounds that regulate the zinc metalloprotease meprin can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including cardiovascular and renal disorders. The invention provides assays for the identification of such compounds.
(FR) Des composés qui ont une action de régulation sur la méprine de métalloprotéase de zinc, peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies comprenant les troubles cardio-vasculaires et les troubles rénaux. La présente invention concerne des essais pour identifier ces composés.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)