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1. (WO2007003536) SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003536 International Application No.: PCT/EP2006/063611
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
IPC:
C07D 409/14 (2006.01) ,C07D 409/12 (2006.01) ,C07D 487/04 (2006.01) ,C07D 413/04 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/55 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Str. 173 55216 Ingelheim Am Rhein, DE (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Str. 173 55216 Ingelheim Am Rhein, DE (DE)
PRIEPKE, Henning [DE/DE]; DE (UsOnly)
DAHMANN, Georg [DE/DE]; DE (UsOnly)
GERLACH, Kai [DE/DE]; DE (UsOnly)
PFAU, Roland [DE/DE]; DE (UsOnly)
WIENEN, Wolfgang [DE/DE]; DE (UsOnly)
SCHULER-METZ, Annette [DE/DE]; DE (UsOnly)
HANDSCHUH, Sandra [DE/DE]; DE (UsOnly)
NAR, Herbert [DE/DE]; DE (UsOnly)
Inventors:
PRIEPKE, Henning; DE
DAHMANN, Georg; DE
GERLACH, Kai; DE
PFAU, Roland; DE
WIENEN, Wolfgang; DE
SCHULER-METZ, Annette; DE
HANDSCHUH, Sandra; DE
NAR, Herbert; DE
Agent:
HAMMANN, Heinz ; Binger Str. 173 55216 Ingelheim Am Rhein, DE
Priority Data:
05014270.230.06.2005EP
Title (DE) SUBSTITUIERTE GLYCINAMIDE MIT ANTITHROMBOTISCHER UND FAKTOR XA-INHIBIERENDER WIRKUNG
(EN) SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT
(FR) GLYCINAMIDES SUBSTITUES A EFFET ANTITHROMBOTIQUE ET INHIBANT LE FACTEUR XA
Abstract:
(DE) Gegenstand der vorliegenden Erfindung sind neue substituierte Glycinamide der allgemeinen Formel (I), in denen D, M, R3, R4 und R5 wie in der Beschreibung definiert sind, deren Tautomere, deren Enantiomere, deren Diastereomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, welche wertvolle Eigenschaften aufweisen.
(EN) The invention relates to novel substituted glycinamides of general formula (I), wherein D, M, R3, R4, and R5 are defined as indicated in the description, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, which are provided with valuable characteristics.
(FR) L'invention a pour objet de nouveaux glycinamides substitués de formule générale (I), dans laquelle D, M, R3, R4 et R5 sont tels que définis dans la description, ainsi que leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, en particulier leurs sels physiologiquement compatibles avec des acides ou des bases inorganiques ou organiques, ces nouveaux composés présentant des propriétés précieuses.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
NO20075186RSP-2011/0015MXMX/a/2007/016253KR1020080033318IL188323SG163540
VN17466PE2007-0171EP1899330BRPI0612580-8ZA2007/08525JP2008546741
ES2357029US20100216769CN101213195US20130184256CA2613059EA200702620
PT1899330US20150252050NZ565440AU2006265216DK1899330ID049.0106
MYPI 20063092TH104937IN9037/DELNP/2007BRPI0612580