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1. (WO2007003420) DETECTION OF A TARGET ANTIGEN IRRESPECTIVE OF THE PRESENCE OR ABSENCE OF A CORRESPONDING THERAPEUTIC ANTIBODY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003420 International Application No.: PCT/EP2006/006524
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
Chapter 2 Demand Filed: 23.01.2007
IPC:
G01N 33/53 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
LENZ, Helmut [DE/DE]; DE (UsOnly)
SCHEUER, Werner [DE/DE]; DE (UsOnly)
THIER, Martina [DE/DE]; DE (UsOnly)
Inventors:
LENZ, Helmut; DE
SCHEUER, Werner; DE
THIER, Martina; DE
Agent:
SCHREINER, Siegfried ; Roche Diagnostics GmbH Patent Department (TR-E) Postfach 11 52 82372 Penzberg, DE
Priority Data:
05014618.206.07.2005EP
06004447.606.03.2006EP
Title (EN) DETECTION OF A TARGET ANTIGEN IRRESPECTIVE OF THE PRESENCE OR ABSENCE OF A CORRESPONDING THERAPEUTIC ANTIBODY
(FR) DETECTION D'UN ANTIGENE CIBLE INDEPENDAMMENT DE LA PRESENCE OU DE L'ABSENCE D'UN ANTICORPS THERAPEUTIQUE CORRESPONDANT
Abstract:
(EN) The present invention relates to the field of therapeutic antibodies. The invention especially relates to a method of detecting the target antigen of a therapeutic antibody in a sample comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with said therapeutic antibody under conditions appropriate for binding of said therapeutic antibody to said target antigen, whereby a target antigen-therapeutic antibody-complex is formed, and c) detecting the complex formed in (b).
(FR) La présente invention concerne les anticorps thérapeutiques. L'invention concerne en particulier une méthode de détection de l'antigène cible d'un anticorps thérapeutique dans un échantillon, consistant a) à obtenir l'échantillon à analyser, b) à incuber ledit échantillon avec l'anticorps thérapeutique dans des conditions adaptées pour la liaison de l'anticorps thérapeutique à l'antigène cible, un complexe antigène cible-anticorps thérapeutique étant ainsi formé, et c) à détecter le complexe formé au cours de l'étape (b).
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20076662MXMX/a/2008/000277KR1020080016939IL188317VN18303EP2194380
EP1902315BRPI0612591-3ZA2008/00083JP2008545145CN101213450CA2613187
NZ564471AU2006265275ID048.0806IN68/CHENP/2008