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1. (WO2007003278) COMPOSITION AND DOSAGE FORM COMPRISING A SOLID OR SEMI-SOLID MATRIX
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003278 International Application No.: PCT/EP2006/006026
Publication Date: 11.01.2007 International Filing Date: 22.06.2006
IPC:
A61K 47/22 (2006.01) ,A61K 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
Applicants:
ABBOTT-GMBH & CO. KG [DE/DE]; Max-Planck-Ring 2 65205 Wiesbaden, DE (AllExceptUS)
ROSENBERG, Jörg [DE/DE]; DE (UsOnly)
MÄGERLEIN, Markus [DE/DE]; DE (UsOnly)
BREITENBACH, Jörg [DE/DE]; DE (UsOnly)
Inventors:
ROSENBERG, Jörg; DE
MÄGERLEIN, Markus; DE
BREITENBACH, Jörg; DE
Agent:
REITSTÖTTER-KINZEBACH; Reitstötter, Kinzebach & Partner (GbR) Sternwartstrasse 4 81679 München, DE
Priority Data:
05014555.605.07.2005EP
60/595,43505.07.2005US
Title (EN) COMPOSITION AND DOSAGE FORM COMPRISING A SOLID OR SEMI-SOLID MATRIX
(FR) COMPOSITION ET FORME GALÉNIQUE COMPRENANT UNE MATRICE SOLIDE OU SEMI-SOLIDE
Abstract:
(EN) A composition which comprises a solid or semi-solid matrix having at least one active ingredient uniformly dispersed therein, the matrix comprising at least one pharmaceutically acceptable matrix-forming agent and a 1,3-bis(lactamyl)-butane compound, in particular 1,3-bis(pyrrolidon-1-yl)-butane. The active ingredient is preferably dispersed in the matrix in a state of a solid solution. The matrix-forming agent is preferably a pharmaceutically acceptable polymer. The composition is useful for the manufacture of pharmaceutical dosage forms.
(FR) La présente invention concerne une composition qui comprend une matrice solide ou semi-solide ayant au moins une substance active dispersée uniformément dans celle-ci, la matrice comprenant au moins un agent de formation de matrice pharmaceutiquement acceptable et un composé de type 1,3-bis(lactamyl)butane, en particulier le 1,3-bis(pyrrolidon-1-yl)butane. La substance active est de préférence dispersée dans la matrice à l’état d’une solution solide. L'agent de formation de matrice est de préférence un polymère pharmaceutiquement acceptable. La composition est utile pour la fabrication de formes galéniques pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1898954JP2009500301US20090220596RU0002423997CN101217981CA2612864
IN72/CHENP/2008