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1. (WO2007003077) PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003077 International Application No.: PCT/CN2005/001913
Publication Date: 11.01.2007 International Filing Date: 14.11.2005
IPC:
C07D 413/12 (2006.01) ,C07D 413/14 (2006.01) ,C07D 237/12 (2006.01) ,C07D 237/20 (2006.01) ,A61K 31/501 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12
Halogen atoms or nitro radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants:
中国人民解放军军事医学科学院毒物药物研究所 INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA [CN/CN]; 中国北京市海淀区太平路27号, Beijing 100850 No. 27, Taiping Road Haidian District Beijing 100850, CN (AllExceptUS)
李松 LI, Song [CN/CN]; CN (UsOnly)
米春来 MI, Chunlai [CN/CN]; CN (UsOnly)
郑志兵 ZHENG, Zhibing [CN/CN]; CN (UsOnly)
赵国明 ZHAO, Guoming [CN/CN]; CN (UsOnly)
周辛波 ZHOU, Xinbo [CN/CN]; CN (UsOnly)
宫泽辉 GONG, Zehui [CN/CN]; CN (UsOnly)
Inventors:
李松 LI, Song; CN
米春来 MI, Chunlai; CN
郑志兵 ZHENG, Zhibing; CN
赵国明 ZHAO, Guoming; CN
周辛波 ZHOU, Xinbo; CN
宫泽辉 GONG, Zehui; CN
Agent:
中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE; 中国北京市阜成门外大街2号万通新世界广场8层, Beijing 100037 8th Floor Vantone New World Plaza 2 Fuchengmenwai Street Beijing 100037, CN
Priority Data:
200510081813.930.06.2005CN
Title (EN) PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS
(FR) DÉRIVÉS DE PYRIDAZINYLAMINE, EMPLOI DESDITS DÉRIVÉS DANS L'ÉLABORATION D'INHIBITEURS DES PICORNAVIRUS
(ZH) 哒嗪胺衍生物及其用于制备小 RNA 病毒抑制剂的用途
Abstract:
(EN) A substituted pyridazinyl amine derivatives of fomula I, and pharmceutical acceptalbe salts or hydrates thereof, preparation method, pharmaceutical compositions containing said compounds, and their use as picorna virus inhibitors in the treatment and prophylaxis of viral diseases induced by picorna virus.
(FR) La présente invention décrit des dérivés substitués de pyridazinylamine de formule I, ainsi que les sels et hydrates de qualité pharmaceutique desdits dérivés, leur méthode de synthèse, des préparations pharmaceutiques contenant lesdits composés, et leur emploi en tant qu'inhibiteurs des picornavirus dans le traitement prophylactique et thérapeutique de maladies virales induites par les picornavirus.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
KR1020080045120EP1900735JP2008546814RU02380366US20080269232US20110059978
ES2386550AU2005334058DK1900735IN636/DELNP/2008