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1. WO2007003056 - CATHEPSIN CYSTEINE PROTEASE INHIBITORS

Publication Number WO/2007/003056
Publication Date 11.01.2007
International Application No. PCT/CA2006/001104
International Filing Date 05.07.2006
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
C07D 231/12 (2006.01)
A61K 31/415 (2006.01)
CPC
C07D 231/12
Applicants
  • MERCK FROSST CANADA LTD. [CA/CA]; 16711 Trans-canada Highway Kirkland, Québec H9H 3L1, CA (AllExceptUS)
  • BLACK, Cameron [CA/CA]; CA (UsOnly)
  • CRANE, Sheldon [CA/CA]; CA (UsOnly)
  • OBALLA, Renata [CA/CA]; CA (UsOnly)
  • ROBICHAUD, Joel [CA/CA]; CA (UsOnly)
Inventors
  • BLACK, Cameron; CA
  • CRANE, Sheldon; CA
  • OBALLA, Renata; CA
  • ROBICHAUD, Joel; CA
Agents
  • OGILVY RENAULT LLP/S.E.N.C.R.L., s.r.l.; Suite 1600 1981 Mcgill College Avenue Montréal, Québec H3A 2Y3, CA
Priority Data
60/696,97006.07.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CATHEPSIN CYSTEINE PROTEASE INHIBITORS
(FR) INHIBITEURS DE CYSTÉINE PROTÉASES DE TYPE CATHEPSINE
Abstract
(EN)
This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of R1 , R2 and R3 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsms K, L, S and B These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.
(FR)
La présente invention concerne une nouvelle classe de composés de formule ci-dessous, où les valeurs de R1, R2 et R3 sont telles qu'indiquées dans la description, lesdits composés étant des inhibiteurs de cystéine protéase, incluant sans y être limité des inhibiteurs des cathepsines K, L, S et B. Ces composés peuvent être employés dans le traitement de maladies pouvant requérir l'inhibition de la résorption des os, telles que l'ostéoporose, l'ostéoarthrite et la polyarthrite rhumatoïde.
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