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1. (WO2007003056) CATHEPSIN CYSTEINE PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/003056 International Application No.: PCT/CA2006/001104
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
C07D 231/12 (2006.01) ,A61K 31/415 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
Applicants:
MERCK FROSST CANADA LTD. [CA/CA]; 16711 Trans-canada Highway Kirkland, Québec H9H 3L1, CA (AllExceptUS)
BLACK, Cameron [CA/CA]; CA (UsOnly)
CRANE, Sheldon [CA/CA]; CA (UsOnly)
OBALLA, Renata [CA/CA]; CA (UsOnly)
ROBICHAUD, Joel [CA/CA]; CA (UsOnly)
Inventors:
BLACK, Cameron; CA
CRANE, Sheldon; CA
OBALLA, Renata; CA
ROBICHAUD, Joel; CA
Agent:
OGILVY RENAULT LLP/S.E.N.C.R.L., s.r.l.; Suite 1600 1981 Mcgill College Avenue Montréal, Québec H3A 2Y3, CA
Priority Data:
60/696,97006.07.2005US
Title (EN) CATHEPSIN CYSTEINE PROTEASE INHIBITORS
(FR) INHIBITEURS DE CYSTÉINE PROTÉASES DE TYPE CATHEPSINE
Abstract:
(EN) This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of R1 , R2 and R3 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsms K, L, S and B These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.
(FR) La présente invention concerne une nouvelle classe de composés de formule ci-dessous, où les valeurs de R1, R2 et R3 sont telles qu'indiquées dans la description, lesdits composés étant des inhibiteurs de cystéine protéase, incluant sans y être limité des inhibiteurs des cathepsines K, L, S et B. Ces composés peuvent être employés dans le traitement de maladies pouvant requérir l'inhibition de la résorption des os, telles que l'ostéoporose, l'ostéoarthrite et la polyarthrite rhumatoïde.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1902031JP2009500300US20090093444CN101218207CN103172568CA2614070
AU2006265735IN259/DELNP/2008