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1. (WO2007002931) PHOSPHORAMIDATE ALKYLATOR PRODRUGS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002931 International Application No.: PCT/US2006/025881
Publication Date: 04.01.2007 International Filing Date: 29.06.2006
IPC:
C07H 19/10 (2006.01) ,C07H 19/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
Applicants:
THRESHOLD PHARMACEUTICALS, INC. [US/US]; 1300 Seaport Boulevard, 5th Floor Redwood City, California 94063, US (AllExceptUS)
MATTEUCCI, Mark [US/US]; US (UsOnly)
DUAN, Jian-Xin [CN/US]; US (UsOnly)
JIAO, Hailong [CA/US]; US (UsOnly)
KAIZERMAN, Jacob; US (UsOnly)
AMMONS, Steve [US/US]; US (UsOnly)
Inventors:
MATTEUCCI, Mark; US
DUAN, Jian-Xin; US
JIAO, Hailong; US
KAIZERMAN, Jacob; US
AMMONS, Steve; US
Agent:
HOPKINS, Mark, H. ; Townsend and Townsend and Crew LLP Two Embarcadero Center, 8th Floor San Francisco, CA 94111, US
Priority Data:
60/695,75529.06.2005US
Title (EN) PHOSPHORAMIDATE ALKYLATOR PRODRUGS
(FR) PRODROGUES D'ALKYLATEUR DE PHOSPHORAMIDATE
Abstract:
(EN) Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
(FR) La présente invention a trait à des prodrogues d'alkylateur de phosphoramidate apte à être utilisés pour le traitement du cancer lorsqu'ils sont administrés seuls ou en combinaison avec un ou des agents anti-néoplasiques.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080442RSP-2012/0449MXMX/a/2007/016341KR1020080027901IL188236EP1896040
BRPI0612845-9ZA2008/00314JP2009502743EP2336141US20100137254JP2012153722
RU0002414475ES2389532CN101501054CN102746336CA2613312ES2579235
NZ565378AU2006263433DK1896040AU2011202075ID048.2318IN257/KOLNP/2008
BRPI0612845