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1. (WO2007002899) THERAPEUTIC APPLICATIONS OF AMINOLEVULINATE SYNTHASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002899 International Application No.: PCT/US2006/025611
Publication Date: 04.01.2007 International Filing Date: 29.06.2006
IPC:
C12Q 1/68 (2006.01) ,A01N 33/00 (2006.01) ,A01N 43/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
33
Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02
having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04
with one hetero atom
Applicants:
UNIVERSITY OF SOUTH FLORIDA [US/US]; 3702 Spectrum Blvd. Suite 155 Tampa, FL 33612, US (AllExceptUS)
HUNTER, Gregory, A. [US/US]; US (UsOnly)
FERREIRA, Gloria, C. [US/US]; US (UsOnly)
LENDRIHAS, Thomas [US/US]; US (UsOnly)
Inventors:
HUNTER, Gregory, A.; US
FERREIRA, Gloria, C.; US
LENDRIHAS, Thomas; US
Agent:
McGAW, Michael, M.; Smith & Hopen, P.A. 180 Pine Avenue North Oldsmar, FL 34677, US
Priority Data:
60/695,17229.06.2005US
Title (EN) THERAPEUTIC APPLICATIONS OF AMINOLEVULINATE SYNTHASE
(FR) APPLICATIONS THERAPEUTIQUES D'AMINOLEVULINATE SYNTHASE
Abstract:
(EN) Systems and methods for increasing protoporphyrin IX accumulation in a target cell population using aminolevulinate synthase variants. Aminolevulinic acid-mediated photodynamic therapy is a promising approach to treating dysplasic disorders such as cancer and atherosclerosis, but is limited by the lack of a means to deliver optimal quantities of aminolevulinic acid selectively to the target cells, and thereby ensure the best therapeutic response. The disclosed invention provides a means for enhancing the natural production of aminolevulinic acid selectively within target cells to levels predetermined to give an optimal therapeutic response, and is expected to lead to increased efficacy of treatment, possibly broadening the scope of diseases treatable by photodynamic therapy considerably. The disclosed invention is also amenable to patient specific therapy, meaning that a patient's target cells could be used to screen for the aminolevulinic acid delivery system most appropriate for the patient's needs.
(FR) L'invention concerne des systèmes et des méthodes destinés à augmenter l'accumulation de protoporphyrine IX dans une population de cellules cibles au moyen de variants d'aminolévulinate synthase. Une thérapie photodynamique médiée par l'acide aminolévulinique constitue une voie prometteuse pour traiter les troubles dysplasiques tels que le cancer et l'athérosclérose, mais est limitée par l'absence d'un moyen d'administration de doses optimales d'acide aminolévulinique sélectivement dans les cellules cibles en vue d'une réponse thérapeutique optimale. L'invention concerne un moyen destiné à augmenter la production naturelle d'acide aminolévulinique sélectivement dans les cellules cibles à des niveaux prédéterminés en vue d'une réponse thérapeutique optimale, ce qui devrait permettre d'obtenir une efficacité de traitement accrue, d'où la possibilité d'élargir considérablement le champ des maladies pouvant être traitées par thérapie photodynamique. La présente invention concerne également un traitement spécifique de patient selon lequel des cellules cibles d'un patient peuvent être utilisées pour identifier le système d'administration d'acide aminolévulinique convenant le mieux aux besoins du patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2612144