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1. (WO2007002886) COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PR0TEIN-LIP1D COMPLEXES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002886 International Application No.: PCT/US2006/025519
Publication Date: 04.01.2007 International Filing Date: 29.06.2006
IPC:
A61K 38/00 (2006.01) ,A61K 35/14 (2006.01) ,A61K 9/127 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK [US/US]; STOR Intellectual Property Division UB Technology Incubator, Suite 111 1576 Sweet Home Road Amherst, NY 14228, US (AllExceptUS)
BALU-IYER, Sathy, V. [US/US]; US (UsOnly)
STRAUBINGER, Robert, M. [US/US]; US (UsOnly)
RAMANI, Karthik [IN/US]; US (UsOnly)
MICLEA, Razvan, D. [US/US]; US (UsOnly)
Inventors:
BALU-IYER, Sathy, V.; US
STRAUBINGER, Robert, M.; US
RAMANI, Karthik; US
MICLEA, Razvan, D.; US
Agent:
KADLE, Ranjana ; Hodgson Russ LLP The Guaranty Building 140 Pearl Street, Suite 100 Buffalo, New York 14202-4040, US
Priority Data:
60/695,08029.06.2005US
Title (EN) COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PR0TEIN-LIP1D COMPLEXES
(FR) COMPOSITIONS ET PROCEDES POUR L'OBTENTION DE COMPLEXES PROTEINES-LIPIDES MOINS IMMUNOGENES
Abstract:
(EN) The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phospatidyl ethanolamine.
(FR) L'invention concerne des compositions et des procédés qui permettent de réduire l'immunogénicité et de prolonger la demi-vie circulante de protéines thérapeutiques, notamment le Factor VIII. Ces compositions contiennent des structures lipidiques telles que les liposomes, les micelles et les cochléaires, qui comportent un lipide de charge négative, ainsi que l'éthanolamine phospatidyl dérivé de polyéthylèneglycol.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2008/000223EP1898939BRPI0612843-2JP2008544990CN101304757CA2613705
NZ565039AU2006263566