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1. (WO2007002886) COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PR0TEIN-LIP1D COMPLEXES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002886    International Application No.:    PCT/US2006/025519
Publication Date: 04.01.2007 International Filing Date: 29.06.2006
IPC:
A61K 38/00 (2006.01), A61K 35/14 (2006.01), A61K 9/127 (2006.01)
Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK [US/US]; STOR Intellectual Property Division, UB Technology Incubator, Suite 111, 1576 Sweet Home Road, Amherst, NY 14228 (US) (For All Designated States Except US).
BALU-IYER, Sathy, V. [US/US]; (US) (For US Only).
STRAUBINGER, Robert, M. [US/US]; (US) (For US Only).
RAMANI, Karthik [IN/US]; (US) (For US Only).
MICLEA, Razvan, D. [US/US]; (US) (For US Only)
Inventors: BALU-IYER, Sathy, V.; (US).
STRAUBINGER, Robert, M.; (US).
RAMANI, Karthik; (US).
MICLEA, Razvan, D.; (US)
Agent: KADLE, Ranjana; Hodgson Russ LLP, The Guaranty Building, 140 Pearl Street, Suite 100, Buffalo, New York 14202-4040 (US)
Priority Data:
60/695,080 29.06.2005 US
Title (EN) COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PR0TEIN-LIP1D COMPLEXES
(FR) COMPOSITIONS ET PROCEDES POUR L'OBTENTION DE COMPLEXES PROTEINES-LIPIDES MOINS IMMUNOGENES
Abstract: front page image
(EN)The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phospatidyl ethanolamine.
(FR)L'invention concerne des compositions et des procédés qui permettent de réduire l'immunogénicité et de prolonger la demi-vie circulante de protéines thérapeutiques, notamment le Factor VIII. Ces compositions contiennent des structures lipidiques telles que les liposomes, les micelles et les cochléaires, qui comportent un lipide de charge négative, ainsi que l'éthanolamine phospatidyl dérivé de polyéthylèneglycol.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)