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1. (WO2007002781) PREPARATIONS COMPRISING ARYLAZINE SUBSTITUTED WITH A CARBONYLIC MOIETY TO INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002781    International Application No.:    PCT/US2006/025240
Publication Date: 04.01.2007 International Filing Date: 28.06.2006
Chapter 2 Demand Filed:    26.04.2007    
IPC:
A61K 31/47 (2006.01), A61P 27/06 (2006.01)
Applicants: BAUSCH & LOMB INCORPORATED [US/US]; One Bausch & Lomb Place, Rochester, NY 14604-2701 (US) (For All Designated States Except US).
PFEFFER, Bruce [US/US]; (US) (For US Only).
FLICK, Rosemarie [US/US]; (US) (For US Only).
BARTELS, Stephen [US/US]; (US) (For US Only)
Inventors: PFEFFER, Bruce; (US).
FLICK, Rosemarie; (US).
BARTELS, Stephen; (US)
Agent: LAVOIE, Paul, T.; Bausch & Lomb Incorporated, One Bausch & Lomb Place, Rochester, NY 14604-2701 (US)
Priority Data:
60/694,726 28.06.2005 US
Title (EN) PREPARATIONS COMPRISING ARYLAZINE SUBSTITUTED WITH A CARBONYLIC MOIETY TO INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS
(FR) PRÉPARATIONS CONTENANT DE L’ARYLAZINE SUBSTITUÉE PAR UNE PORTION CARBONYLIQUE AFIN D’AUGMENTER L’ACTIVITÉ DE LA GÉLATINASE A DANS LES CELLULES OCULAIRES
Abstract: front page image
(EN)Preparations for controlling intraocular pressure in the eye comprise as an active compound, arylazine substituted with a carbonylic moiety, which compound is capable of effecting a 'pharmacological trabeculocanalotomy' in an eye by means of reducing juxtacanalicular meshwork to promote outflow of aqueous. The organic active compound increases Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for glaucoma, e.g., primary open angle glaucoma.
(FR)Cette invention concerne des préparations destinées à contrôler la pression intraoculaire de l’œil comprenant, en tant queprincipe actif, l’arylazine substituée par une portion carbonylique. Ledit principe actif est capable d’effectuer une 'trabéculocanalotomie pharmacologique' dans un œil en réduisant le maillage juxtacanaliculaire pour faciliter l’écoulement vers l’extérieur de l’humeur aqueuse. Le principe actif organique accroît l’activité de la gélatinase A dans les cellules oculaires en augmentant l’expression membranaire cellulaire des métalloprotéinases matricielles de type membranaire (MT-MMP) afin d’augmenter l’écoulement vers l’extérieur d’humeur aqueuse. Ces préparations sont utiles dans le traitement du glaucome, , tel le glaucome primaire à angle ouvert par exemple.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)