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Machine translation
1. (WO2007002677) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MONITORING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002677    International Application No.:    PCT/US2006/025003
Publication Date: 04.01.2007 International Filing Date: 26.06.2006
IPC:
G01N 33/48 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real, Palo Alto, California 94306-1106 (US) (For All Designated States Except US).
TABIBIAZAR, Raymond [US/US]; (US) (For US Only).
TSAO, Philip S. [US/US]; (US) (For US Only).
QUERTERMOUS, Thomas [US/US]; (US) (For US Only).
TURNBULL, Brit Katzen [US/US]; (US) (For US Only).
OLSHEN, Richard A. [US/US]; (US) (For US Only).
HYTOPOULOS, Evangelos [GR/US]; (US) (For US Only)
Inventors: TABIBIAZAR, Raymond; (US).
TSAO, Philip S.; (US).
QUERTERMOUS, Thomas; (US).
TURNBULL, Brit Katzen; (US).
OLSHEN, Richard A.; (US).
HYTOPOULOS, Evangelos; (US)
Agent: SHERWOOD, Pamela J.; BOZICEVIC, FIELD & FRANCIS LLP, 1900 University Avenue, Suite 200, East Palo Alto, California 94303 (US)
Priority Data:
60/693,756 24.06.2005 US
11/473,826 23.06.2006 US
Title (EN) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MONITORING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
(FR) METHODES ET COMPOSITIONS POUR LE DIAGNOSTIC ET LA SURVEILLANCE D'UNE MALADIE CARDIOVASCULAIRE ATHEROSCLEREUSE
Abstract: front page image
(EN)The present invention identifies circulating proteins that are differentially expressed in atherosclerosis. Circulating levels of these proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.
(FR)La présente invention permet d'identifier des protéines circulantes exprimées de manière différentielle dans l'athérosclérose. Les niveaux de circulation de ces protéines, notamment sous la forme d'un panel de protéines, permettent de distinguer les patients qui présentent un infarctus du myocarde aigu de ceux qui présentent une angine d'effort stable et de ceux qui ne présentent pas d'historique de maladie cardiovasculaire athéroscléreuse. Ces niveaux permettent également de prédire des événements cardiovasculaires, de déterminer l'efficacité d'un traitement, de déterminer le stade d'une maladie, etc. Par exemple, ces marqueurs sont utiles comme biomarqueurs de substitution d'événements cliniques nécessaires pour la mise au point d'agents pharmaceutiques vasculaires spécifiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)