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1. (WO2007002654) LXR LIGAND TESTING METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002654 International Application No.: PCT/US2006/024945
Publication Date: 04.01.2007 International Filing Date: 26.06.2006
IPC:
C12Q 1/00 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
DAIICHI SANKYO COMPANY, LIMITED. [JP/JP]; 5-1, Nihonbashi Honcho 3-chome Chuo-ku, Tokyo 103-8426, JP (AllExceptUS)
TERASAKA, Naoki [JP/JP]; JP (UsOnly)
HONZUMI, Shoko [JP/JP]; JP (UsOnly)
SCHULMAN, Ira Glenn [US/US]; US (UsOnly)
WAGNER, Brandee Lynn [US/US]; US (UsOnly)
WILLY, Patricia J. [US/US]; US (UsOnly)
Inventors:
TERASAKA, Naoki; JP
HONZUMI, Shoko; JP
SCHULMAN, Ira Glenn; US
WAGNER, Brandee Lynn; US
WILLY, Patricia J.; US
Agent:
BARTH, Richard, S. ; FRISHAUF, HOLTZ, GOODMAN & CHICK, P.C. 220 Fifth Avenue, 16th Floor New York, NY 10001-7708, US
Priority Data:
60/694,80628.06.2005US
Title (EN) LXR LIGAND TESTING METHOD
(FR) METHODE D'ESSAI DE LIGAND LXR
Abstract:
(EN) A method of easily measuring whether or not an LXR ligand has the function of effecting, e.g., increasing, plasma triglyceride concentration and/or LDL cholesterol concentration in a mammal by using the binding activity between LXR and a coactivator, and a method of identifying LXR ligands that do not have the function of effecting, e.g., increasing, plasma triglyceride concentration and/or LDL cholesterol concentration by using the binding activity between LXR and a coactivator.
(FR) L'invention concerne une méthode de mesure simple permettant de savoir si oui ou non un ligand LXR a la fonction d'effectuer, par exemple d'augmenter, la concentration en triglycérides dans le plasma et/ou la concentration en cholestérol LDL chez un mammifère par utilisation de l'activité de liaison entre LXR et un coactivateur ainsi qu'une méthode d'identification de ligands LXR n'ayant pas la fonction d'effectuer, par exemple d'augmenter, la concentration en triglycérides du plasma et/ou la concentration en cholestérol LDL par utilisation de l'activité de liaison entre LXR et un coactivateur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1907564JP2008546423US20090098570ES2438739