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1. (WO2007002638) ANTI-MARINOBUFAGENIN ANTIBODIES AND METHODS FOR THEIR USE

Pub. No.:    WO/2007/002638    International Application No.:    PCT/US2006/024918
Publication Date: Jan 4, 2007 International Filing Date: Jun 26, 2006
IPC: C12N 5/20
A61K 39/395
G01N 33/74
G01N 33/577
A61P 9/00
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
BAGROV, Alexei
FEDOROVA, Olga, V.
LAKATTA, Edward, G.
SIMBIRTSEV, Andrey
KOTOV, Alexander
KOLODKIN, Nikolai
Inventors: BAGROV, Alexei
FEDOROVA, Olga, V.
LAKATTA, Edward, G.
SIMBIRTSEV, Andrey
KOTOV, Alexander
KOLODKIN, Nikolai
Title: ANTI-MARINOBUFAGENIN ANTIBODIES AND METHODS FOR THEIR USE
Abstract:
Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also encompasses the use of these monoclonal antibodies or antigen binding fragments in a method for detecting the presence of marinobufagenin in a biological sample. Also provided are methods for the use of these monoclonal antibodies or antigen binding fragments as prophylactic, therapeutic, and diagnostic agents for the detection, inhibition and treatment of a cardiovascular disease, for example, essential hypertension, hypertension associated with preeclampsia, eclampsia, or renal failure, or myocardial fibrosis in a subject.