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1. (WO2007002559) PYRAZOLE BASED LXR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002559    International Application No.:    PCT/US2006/024749
Publication Date: 04.01.2007 International Filing Date: 26.06.2006
IPC:
C07D 233/54 (2006.01), C07D 401/04 (2006.01), C07D 409/04 (2006.01), A61K 31/415 (2006.01), A61P 3/10 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; 210 East Grand Avenue, P.O. Box 511, South San Francisco, CA 94083-0511 (US) (For All Designated States Except US).
BUSCH, Brett, B. [US/US]; (US) (For US Only).
FLATT, Brenton, T. [US/US]; (US) (For US Only).
GU, Xiao-Hui [CN/US]; (US) (For US Only).
LU, Shao-Po [US/US]; (US) (For US Only).
MARTIN, Richard [CA/US]; (US) (For US Only).
MOHAN, Raju [US/US]; (US) (For US Only).
NYMAN, Michael, Charles [US/US]; (US) (For US Only).
SCHWEIGER, Edwin [US/US]; (US) (For US Only).
STEVENS, William, C., Jr. [US/US]; (US) (For US Only).
WANG, Tie-Lin [US/US]; (US) (For US Only).
XIE, Yinong [CN/US]; (US) (For US Only)
Inventors: BUSCH, Brett, B.; (US).
FLATT, Brenton, T.; (US).
GU, Xiao-Hui; (US).
LU, Shao-Po; (US).
MARTIN, Richard; (US).
MOHAN, Raju; (US).
NYMAN, Michael, Charles; (US).
SCHWEIGER, Edwin; (US).
STEVENS, William, C., Jr.; (US).
WANG, Tie-Lin; (US).
XIE, Yinong; (US)
Agent: GREENFIELD, Michael, S.; McDonnell Boehnen Hulbert & Berghoff LLP, 300 South Wacker Drive, Suite 3100, Chicago, IL 60606 (US)
Priority Data:
60/694,372 27.06.2005 US
60/736,120 10.11.2005 US
Title (EN) PYRAZOLE BASED LXR MODULATORS
(FR) MODULATEURS DES LXR A BASE DE PYRAZOLES
Abstract: front page image
(EN)Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
(FR)L'invention concerne des composés, représentés notamment par les formules Ia, Ib, Ic ou Id, ainsi que des promédicaments, des isomères et des sels pharmaceutiquement acceptables de ceux-ci, ces composés présentant une utilité comme modulateurs de l'activité des récepteurs X du foie (LXR). Dans les formules susmentionnées, R1, R2, R21, R3 et G sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que des méthodes d'utilisation desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)