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1. (WO2007002540) RADIOLABELED-PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002540 International Application No.: PCT/US2006/024707
Publication Date: 04.01.2007 International Filing Date: 26.06.2006
IPC:
A61K 51/00 (2006.01) ,A61K 36/14 (2006.01) ,A61K 9/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
13
Coniferophyta (gymnosperms)
14
Cupressaceae (Cypress family), e.g. juniper or cypress
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
Applicants:
KUNG, Hank F. [US/US]; US
Inventors:
KUNG, Hank F.; US
Agent:
COVERT, JOHN M. ; STERNE, KESSLER, GOLDSTEIN & FOX P.L.L.C. 1100 New York Avenue, N.w. Washington, District Of Columbia 20005, US
Priority Data:
60/693,50124.06.2005US
Title (EN) RADIOLABELED-PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS
(FR) PEGYLATION RADIOMARQUEE DE LIGANDS DESTINES A ETRE UTILISES COMME AGENTS D'IMAGERIE
Abstract:
(EN) The present invention is directed to a method of using radiolabeled ethylene glycol (n = 1) (EG) or polyethylene glycol (n = from 2 to 10) (PEG) as a labeling group moiety on compounds that can be useful for imaging tissues. Specifically, the EG or PEG moiety preferably contains a radiofluorine (18F), and is covalently bonded to a ligand (L). The L portion of the molecule can be any molecule appropriate for covalently bonding with the radiolabeled EG or PEG moiety and subsequent use as an imaging agent. In particular, the imaging agent is preferably an agent suitable for administering to a mammal and detecting by PET or SPECT imaging.
(FR) L'invention porte sur un procédé d'utilisation d'éthylène glycol (n = 1) (EG) ou de polyéthylène glycol (n = de 2 à 10) (PEG) radiomarqué comme fragment d'un groupe d'étiquetage sur des composés qui peuvent être utilisés dans l'imagerie des tissus. En particulier, le fragment EG ou PEG contient de préférence un radiofluor (18F) et est lié par covalence à un ligand (L). La partie L de la molécule peut être n'importe quelle molécule appropriée à la liaison covalente avec le fragment EG ou PEG radiomarqué et pouvant être ensuite utilisée comme agent d'imagerie. Plus particulièrement, l'agent d'imagerie est de préférence un agent apte à être administré à un mammifère et à être détecté par imagerie PET ou SPECT.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1893245JP2008546804CA2617319AU2006261917