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Machine translation
1. (WO2007002457) HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002457    International Application No.:    PCT/US2006/024568
Publication Date: 04.01.2007 International Filing Date: 23.06.2006
IPC:
A61K 31/4035 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
JIANG, Jinlong [US/US]; (US) (For US Only).
DEVITA, Robert, J. [US/US]; (US) (For US Only).
KUMAR, Sanjeev [IN/US]; (US) (For US Only).
MILLS, Sander, G. [US/US]; (US) (For US Only).
TSCHIRRET-GUTH, Richard, A. [FR/US]; (US) (For US Only)
Inventors: JIANG, Jinlong; (US).
DEVITA, Robert, J.; (US).
KUMAR, Sanjeev; (US).
MILLS, Sander, G.; (US).
TSCHIRRET-GUTH, Richard, A.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/694,481 27.06.2005 US
Title (EN) HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DES RECEPTEURS DE TACHYKININE HYDRO-ISO-INDOLIQUE
Abstract: front page image
(EN)The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
(FR)La présente invention concerne certains composés hydro-iso-indoliques utiles en tant qu’antagonistes des récepteurs de la neurokinine-1 (NK-1) et inhibiteurs de la tachykinine, tout particulièrement de la substance P. L’invention concerne également les formulations pharmaceutiques contenant ces composés en tant qu’ingrédients actifs, ainsi que l’utilisation de ces composés et de leurs formulations pour le traitement de certains troubles, tels que les vomissements, l’incontinence urinaire, la dépression et l’anxiété.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)