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1. (WO2007002419) CONFORMER-SPECIFIC ANTIBODIES AND METHOD OF USE, THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002419 International Application No.: PCT/US2006/024506
Publication Date: 04.01.2007 International Filing Date: 22.06.2006
IPC:
C07K 16/06 (2006.01) ,C07K 16/28 (2006.01) ,G01N 33/68 (2006.01) ,C07K 14/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
06
from serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
PROSETTA CORPORATION [US/US]; 670 Fifth Street San Francisco, California 94107, US (AllExceptUS)
LINGAPPA, Vishwanath [US/US]; US (UsOnly)
PRASAD, Mahadevappa Dharma [IN/US]; US (UsOnly)
HANSEN, William [US/US]; US (UsOnly)
LEHRER-GRAIWER, Joshua [US/US]; US (UsOnly)
KORTH, Carsten [DE/DE]; DE (UsOnly)
Inventors:
LINGAPPA, Vishwanath; US
PRASAD, Mahadevappa Dharma; US
HANSEN, William; US
LEHRER-GRAIWER, Joshua; US
KORTH, Carsten; DE
Agent:
SACHDEVA, Gurjeev K.; Foley & Lardner Llp 1530 Page Mill Road Palo Alto, California 94304-1125 , US
Priority Data:
60/693,13622.06.2005US
Title (EN) CONFORMER-SPECIFIC ANTIBODIES AND METHOD OF USE, THEREOF
(FR) ANTICORPS SPECIFIQUES DES CONFORMERES ET METHODE D'UTILISATION DES ANTICORPS
Abstract:
(EN) A number of polypeptides exist in different three-dimensional conformations, or 'conformers,' which have different biological functions despite having the same or substantially the same primary polypeptide sequences. The existence of different polypeptide conformers underlies to a variety of disease states, which may be assessed using antibody that is specific for a given conformer. Thus, such antibody thus is useful for identifying or detecting certain conformers within a mixed population of conformers.
(FR) Selon l'invention, il existe de nombreux polypeptides de différentes conformations tridimensionnelles, ou 'conformères', qui présentent différentes fonctions biologiques bien que possédant des séquences polypeptidiques primaires identiques ou sensiblement identiques. L'existence de différents conformères polypeptidiques indique la présence de divers états de maladies qui peuvent être déterminés au moyen d'un anticorps spécifique d'un conformère donné. Ainsi, un tel anticorps est utile pour l'identification et la détection de certains conformères dans une population mixte de conformères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)