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1. (WO2007002356) METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002356 International Application No.: PCT/US2006/024415
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
A61K 31/415 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
Applicants:
SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION [US/US]; Csab 253 Mobile, AL 36688, US (AllExceptUS)
CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND [US/US]; 5700 Martin Luther King Jr. Way Oakland, CA 94609, US (AllExceptUS)
BAILEY, Steven, W. [US/US]; US (UsOnly)
AYLING, June, E. [US/US]; US (UsOnly)
OFFER, Tal [IL/IL]; IL (UsOnly)
LENTON, Kevin, J. [CA/CA]; CA (UsOnly)
Inventors:
BAILEY, Steven, W.; US
AYLING, June, E.; US
OFFER, Tal; IL
LENTON, Kevin, J.; CA
Agent:
ROGALSKYJ, Peter ; ROGALSKYJ & WEYAND LLP P.O. Box 44 Livonia, NY 14487-0044, US
Priority Data:
60/692,40121.06.2005US
Title (EN) METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE
(FR) METHODES ET COMPOSITIONS CONTENANT DES FOLATES NATURELS POUR PROTECTION CONTRE LES RADIOLESIONS
Abstract:
(EN) Disclosed are methods for protecting a subject from harmful effects of ionizing radiation. The method includes administering to the subject an effective amount of at least one reduced folate. Also disclosed are radioprotective compositions that include a first radioprotective agent and a second radioprotective agent, where the first radioprotective agent is a reduced folate. Methods for protecting a subject from harmful effects of ultraviolet radiation are also disclosed.
(FR) L'invention concerne des méthodes destinées à protéger un sujet contre les effets nuisibles d'un rayonnement ionisant. Cette méthode consiste à administrer à ce sujet une dose efficace d'au moins un folate réduit. L'invention concerne également des compositions radioprotectrices renfermant un premier agent radioprotecteur et un second agent radioprotecteur, le premier agent radioprotecteur étant un folate réduit. L'invention se rapporte en outre à des méthodes destinées à protéger un sujet contre les effets nuisibles d'un rayonnement ultraviolet.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1912641JP2008546799US20090170858CN101203221CA2611636AU2006262096