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1. (WO2007002306) COMPOSITIONS AND METHODS FOR NERVE REGENERATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002306 International Application No.: PCT/US2006/024333
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
A61K 38/17 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; Office of Technology Management 10010 N. Torrey Pines Road La Jolla, CA 92037-1099, US (AllExceptUS)
SUNG, Tsung-Chang [CN/US]; US (UsOnly)
LEE, Kuo-Fen [US/US]; US (UsOnly)
Inventors:
SUNG, Tsung-Chang; US
LEE, Kuo-Fen; US
Agent:
GORDON, Debra, A.; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204, US
Priority Data:
60/693,57123.06.2005US
Title (EN) COMPOSITIONS AND METHODS FOR NERVE REGENERATION
(FR) COMPOSITIONS ET PROCEDES DE REGENERATION NERVEUSE
Abstract:
(EN) This disclosure demonstrates that p45 promotes rapid regeneration of CNS nerves and axons (for example, in the corticospinal tract and/or raphespinal tract) and locomotor functional recovery following complete spinal cord transection in an adult subject. This remarkable discovery as well as disclosed mapping of p45 functional regions enables, for instance, compositions and methods (e.g., in vivo and in vitro methods), involving p45 proteins, fragments and variants, for promoting nerve growth and/or regeneration, and methods for identifying agents having potential nerve-regenerating activity.
(FR) Cette invention prouve que p45 favorise une régénération rapide des nerfs CNS et des axones, notamment dans le conduit corticospinal et/ou raphéspinal, et la récupération fonctionnelle locomotrice suite à un syndrome de section complète de la moelle chez un malade adulte. Cette découverte est remarquable en ce qu'elle permet le mappage de région fonctionnelle p45, notamment des compositions et des méthodes (in vivo et in vitro), implique des protéines p45, des fragments et des variantes de celles-ci en vue d'une croissance et/ou régénération nerveuse et permet l'obtention de procédés d'identification d'agents ayant une activité potentielle de régénération nerveuse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)