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1. (WO2007002306) COMPOSITIONS AND METHODS FOR NERVE REGENERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002306    International Application No.:    PCT/US2006/024333
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
A61K 38/17 (2006.01), G01N 33/68 (2006.01)
Applicants: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; Office of Technology Management, 10010 N. Torrey Pines Road, La Jolla, CA 92037-1099 (US) (For All Designated States Except US).
SUNG, Tsung-Chang [CN/US]; (US) (For US Only).
LEE, Kuo-Fen [US/US]; (US) (For US Only)
Inventors: SUNG, Tsung-Chang; (US).
LEE, Kuo-Fen; (US)
Agent: GORDON, Debra, A.; Klarquist Sparkman, LLP, One World Trade Center, Suite 1600, 121 SW Salmon Street, Portland, OR 97204 (US)
Priority Data:
60/693,571 23.06.2005 US
Title (EN) COMPOSITIONS AND METHODS FOR NERVE REGENERATION
(FR) COMPOSITIONS ET PROCEDES DE REGENERATION NERVEUSE
Abstract: front page image
(EN)This disclosure demonstrates that p45 promotes rapid regeneration of CNS nerves and axons (for example, in the corticospinal tract and/or raphespinal tract) and locomotor functional recovery following complete spinal cord transection in an adult subject. This remarkable discovery as well as disclosed mapping of p45 functional regions enables, for instance, compositions and methods (e.g., in vivo and in vitro methods), involving p45 proteins, fragments and variants, for promoting nerve growth and/or regeneration, and methods for identifying agents having potential nerve-regenerating activity.
(FR)Cette invention prouve que p45 favorise une régénération rapide des nerfs CNS et des axones, notamment dans le conduit corticospinal et/ou raphéspinal, et la récupération fonctionnelle locomotrice suite à un syndrome de section complète de la moelle chez un malade adulte. Cette découverte est remarquable en ce qu'elle permet le mappage de région fonctionnelle p45, notamment des compositions et des méthodes (in vivo et in vitro), implique des protéines p45, des fragments et des variantes de celles-ci en vue d'une croissance et/ou régénération nerveuse et permet l'obtention de procédés d'identification d'agents ayant une activité potentielle de régénération nerveuse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)