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1. (WO2007002285) METHODS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/002285    International Application No.:    PCT/US2006/024303
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
A61K 38/00 (2006.01), A61K 31/70 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
HAYDON, Philip, G. [GB/US]; (US) (For US Only).
HALASSA, Michael, M. [JO/US]; (US) (For US Only).
FELLIN, Tommaso [IT/US]; (US) (For US Only).
DING, Shinghua [CN/US]; (US) (For US Only).
ZHU, Yingzi [CN/US]; (US) (For US Only)
Inventors: HAYDON, Philip, G.; (US).
HALASSA, Michael, M.; (US).
FELLIN, Tommaso; (US).
DING, Shinghua; (US).
ZHU, Yingzi; (US)
Agent: CALDWELL, John; Woodcock Washburn LLP, 2929 Arch Street - Suite 1200, Philadelphia, PA 19104-2891 (US)
Priority Data:
60/692,513 21.06.2005 US
Title (EN) METHODS FOR TREATING NEUROLOGICAL AND PSYCHIATRIC CONDITIONS
(FR) PROCEDES PERMETTANT DE TRAITER DES ETATS NEUROLOGIQUES ET PSYCHIATRIQUES
Abstract: front page image
(EN)The present invention features novel methods for treating neurological and psychiatric conditions. The inventive methods comprise modulating the production or activity of one or more proteins that participate in calcium signaling or glutamate release in astrocytes, modulating the production or activity of one or more proteins that regulate the action of glial glutamate, modulating the concentration of calcium in the neuronal cell, modulating the expression or release of D-serine, or modulating the expression or release of ATP or adenosine. Methods to screen test compounds for their ability to target the specified pathways or cellular calcium are also disclosed.
(FR)L'invention concerne de nouveaux procédés permettant de traiter des états neurologiques et psychiatriques. Les procédés de l'invention consistent à moduler la production ou l'activité d'une ou plusieurs protéines intervenant dans la signalisation calcium ou la libération de glutamate dans les astrocytes, à moduler la production ou l'activité d'une ou plusieurs protéines régulant l'action du glial glutamate, à moduler la concentration de calcium dans la cellule neuronale, à moduler l'expression ou la libération de la D-sérine, ou à moduler l'expression ou la libération de l'ATP ou de l'adénosine. L'invention se rapporte aussi à des procédés permettant de trier des composés d'essai en fonction de leur capacité à cibler les voies spécifiées ou le calcium cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)