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1. (WO2007002261) IL-1&bgr; BINDING ANTIBODIES AND FRAGMENTS THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/002261 International Application No.: PCT/US2006/024261
Publication Date: 04.01.2007 International Filing Date: 21.06.2006
IPC:
C07K 16/24 (2006.01) ,C07K 16/00 (2006.01) ,A61P 37/06 (2006.01) ,A61K 39/395 (2006.01) ,C12N 5/12 (2006.01) ,C12N 15/85 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
XOMA TECHNOLOGY LTD. [US/US]; C/O XOMA (US) LLC 2910 Seventh Street Berkeley, CA 94710, US (AllExceptUS)
MASAT, Linda [IT/US]; US
HAAK-FRENDSCHO, Mary [US/US]; US
CHEN, Gang [US/US]; US
HORWITZ, Arnold [US/US]; US
ROELL, Marina [US/US]; US
Inventors:
MASAT, Linda; US
HAAK-FRENDSCHO, Mary; US
CHEN, Gang; US
HORWITZ, Arnold; US
ROELL, Marina; US
Agent:
HARLIN, Michael, B.; MCANDREWS, HELD & MALLOY, LTD. 500 W. Madison St., 34th Floor Chicago, IL 60661, US
Priority Data:
60/692,83021.06.2005US
Title (EN) IL-1&bgr; BINDING ANTIBODIES AND FRAGMENTS THEREOF
(FR) ANTICORPS BLOQUANT IL-1$G(B) ET LEURS FRAGMENTS
Abstract:
(EN) An IL- 1&bgr; binding antibody or IL- 1&bgr; binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL- 1&bgr; binding polypeptide. IL- 1&bgr;binding antibodies or IL- 1&bgr; binding fragments thereof are provided which have desirable affinity and potency.
(FR) L'invention se rapporte à un anticorps bloquant IL- 1ß ou à un de ses fragments bloquant IL- 1ß et présentant la séquence d'aminoacides de SEQ ID NO: 2, l'invention se rapporte également à des acides nucléiques, des vecteurs, des cellules et des compositions associées; l'invention concerne également un procédé d'utilisation desdits anticorps et fragments dans le traitement ou la prévention d'une maladie, ainsi qu'un procédé de préparation d'un polypeptide bloquant IL- 1ß présentant une maturation d'affinité. L'invention concerne également des anticorps bloquant IL- 1ß ou des fragments de ces derniers bloquant IL- 1ß, lesdits anticorps et fragments présentant une affinité et un pouvoir antigénique désirables.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2007/016032KR1020080039875IL188094IL202630EP2163562EP1899378
EP2314623EP2322552ZA2008/00555JP2008543340ES2391334CN101228188
CN102775493CA2612760RU0002518295ES2439709PT2163562PT1899378
PT2314623CA2873914KR1020130076901KR1020140139618ES2569917EP3056511
NZ565138AU2006262179DK1899378DK2314623DK2163562DK2322552
AU2011205166MX348154IN981/CHENP/2015IN979/CHENP/2015IN980/CHENP/2015IN320/CHENP/2008
PT2322552BRPI0612273